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2.A.6.2.39
THe MuxABC-OpmB multidrug (aztreonam, macrolides, novobiocin and tetracycline) resistance efflux pump complex (with two RND-type proteins (MuxB and MuxC)), both required for activity (Mima et al., 2009).

Accession Number:Q9I0V8
Protein Name:Probable outer membrane protein
Length:498
Molecular Weight:53869.00
Species:Pseudomonas aeruginosa [287]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Aztreonam, Macrolides, Novobiocin, tetracycline

Cross database links:

HEGENOM: HBG759011
RefSeq: NP_251215.1   
Entrez Gene ID: 878719   
Pfam: PF02321   
BioCyc: PAER208964:PA2525-MONOMER   
KEGG: pae:PA2525   

Gene Ontology

GO:0016020 C:membrane
GO:0008289 F:lipid binding
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.”  Stover C.K.et.al.   10984043

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKHTPSLLAL ALVAALGGCA IGPDYQRPDL AVPAEFKEAE GWRRAEPRDV FQRGAWWELY 
61:	GDQTLNDLQM HLERSNQTLA QSVAQFRQAE ALVRGARAAF FPSITGNVGK TRSGQGGGDS 
121:	TVLLPGGSTV SSGGSGAIST SYSTNLSVSW EVDLWGKLRR QLEANQASLH ASAADLAAVR 
181:	LSQQSQLAQN YLQLRVMDEQ IRLLNDTVTA YERSLKVAEN KYRAGIVTRA DVAQARTQLK 
241:	STQAQAIDLK YQRAQLEHAI AVLVGLPPAQ FNLPPVASVP KLPDLPAVVP SQLLERRPDI 
301:	ASAERKVISA NAQIGVAKAA YFPDLTLSAA GGYRSGSLSN WISTPNRFWS IGPQFAMTLF 
361:	DGGLIGSQVD QAEATYDQTV ATYRQTVLDG FREVEDYLVQ LSVLDEESGV QREALESARE 
421:	ALRLAENQYK AGTVDYTDVV TNQATALSNE RTVLTLLGSR LTASVQLIAA MGGGWDSADI 
481:	ERTDERLGRV EEGLPPSP