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1.A.9.2.2
The heteromeric serotonin 5HT3A receptor (Hanna et al., 2000)

Accession Number:Q9JJ16
Protein Name:5-hydroxytryptamine 3 receptor B subunit aka Htr3b aka 5HT3B
Length:437
Molecular Weight:50336.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: Q9JJ16
eggNOG: roNOG05248
RefSeq: NP_071525.1   
Entrez Gene ID: 58963   
Pfam: PF02931    PF02932   
KEGG: rno:58963   

Gene Ontology

GO:0030424 C:axon
GO:0043025 C:neuronal cell body
GO:0045211 C:postsynaptic membrane
GO:0004993 F:serotonin receptor activity
GO:0071363 P:cellular response to growth factor stimulus
GO:0006811 P:ion transport

References (3)

[1] “Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents.”  Hanna M.C.et.al.   10854267
[2] “Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system.”  Morales M.et.al.   12151552
[3] “A cytoplasmic region determines single-channel conductance in 5-HT3 receptors.”  Kelley S.P.et.al.   12867984

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MILLWSCLLV AVVGILGTAT PQPGNSSLHR LTRQLLQQYH KEVRPVYNWA EATTVYLDLC 
61:	VHAVLDVDVQ NQKLKTSMWY REVWNDEFLS WNSSLFDDIQ EISLPLSAIW APDIIINEFV 
121:	DVERSPDLPY VYVNSSGTIR NHKPIQVVSA CSLQTYAFPF DIQNCSLTFN SILHTVEDID 
181:	LGFLRNQEDI ENDKRSFLND SEWQLLSVTS TYHIRQSSAG DFAQIRFNVV IRRCPLAYVV 
241:	SLLIPSIFLM LVDLGSFYLP PNCRARIVFK TNVLVGYTVF RVNMSDEVPR SAGCTSLIGV 
301:	FFTVCMALLV LSLSKSILLI KFLYEERHSE QERPLMCLRG DSDANESRLY LRAPCAEDTE 
361:	SPVRQEHQVP SDTLKDFWFQ LQSINNSLRT RDQVYQKEVE WLAILCHFDQ LLFRIYLAVL 
421:	GLYTVTLCSL WALWSRM