TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.6.2.10
Solvent efflux pump, TtgDEF (extrudes only toluene and styrene) (Teran et al., 2007).

Accession Number:Q9KWV5
Protein Name:TtgD
Length:382
Molecular Weight:41585.00
Species:Pseudomonas putida [303]
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate Toluene, Styrene

Cross database links:

Pfam: PF00529   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion

References (3)

[1] “A set of genes encoding a second toluene efflux system in Pseudomonas putida DOT-T1 is linked to the tod genes for toluene metabolism.”  Mosqueda G.et.al.   10648517
[2] “Global and cognate regulators control the expression of the organic solvent efflux pumps TtgABC and TtgDEF of Pseudomonas putida.”  Duque E.et.al.   11251828
[3] “Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1E.”  Rojas A.et.al.   11395460

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MRLERALRAR QLIPLAAIWL LVGCGKQETV ESTAVPPEVG VYTVKAQALT LTTDLPGRTS 
61:	AYRVSEVRPQ ASGILQKRMF VEGAEVKQGE QLYQIDPRTY EALLARAEAS LLTAQNLARR 
121:	YERLLDTNAI SQQQYDDAMA TWKQAQAEAQ MARINMQYTK VLAPITGRIG RSAVTEGALV 
181:	TNGQAQELAT VTQLDPIYVD VNQPITRLLG LKRALESGRL QRVGDNQAQV SLTLDDGTPY 
241:	PLKGVLKFSE VSVAPSTGSV TLRAEFPNPD HKLLPGMFVH ALLNEGEQQA AILVPHQAVG 
301:	RDARGVPTVW VVKPDNTVES REVQTLQTVG NAWLLGAGIN DGERVITEGV QLARSGIKVK 
361:	PVAAKNVKLM SEFGSQVQAQ AH