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3.A.1.1.22
The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins.

Accession Number:Q9S5Y1
Protein Name:MalE2; aka Maltose ABC transporter, periplasmic maltose-binding protein
Length:393
Molecular Weight:42987.00
Species:Thermotoga maritima [2336]
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Single-pass type II membrane protein2 / Intermembrane side3
Substrate Maltose, Maltotriose, Maltotetraose, Trehalose

Cross database links:

HEGENOM: HBG727666
RefSeq: NP_229635.1   
Entrez Gene ID: 897815   
Pfam: PF01547   
BioCyc: TMAR243274:TM_1839-MONOMER   
KEGG: tma:TM1839   

Gene Ontology

GO:0005363 F:maltose transmembrane transporter activity
GO:0015768 P:maltose transport

References (1)

[1] “Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.”  Nelson K.E.et.al.   10360571
Structure:
2FNC     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVKRLLVLML VVVSALVLSQ TKLTIWCSEK QVDILQKLGE EFKAKYGIPV EVQYVDFGSI 
61:	KSKFLTAAPQ GQGADIIVGA HDWVGELAVN GLIEPIPNFS DLKNFYDTAL KAFSYGGKLY 
121:	GVPYAMEAVA LIYNKDYVDS VPKTMDELIE KAKQIDEEYG GEVRGFIYDV ANFYFSAPFI 
181:	LGYGGYVFKE TPQGLDVTDI GLANEGAVKG AKLIKRMIDE GVLTPGDNYG TMDSMFKEGL 
241:	AAMIINGLWA IKSYKDAGIN YGVAPIPELE PGVPAKPFVG VQGFMINAKS PNKVIAMEFL 
301:	TNFIARKETM YKIYLADPRL PARKDVLELV KDNPDVVAFT QSASMGTPMP NVPEMAPVWS 
361:	AMGDALSIII NGQASVEDAL KEAVEKIKAQ IEK