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2.A.6.2.9
Solvent efflux pump, TtgABC (extrudes toluene, styrene, m-xylene, ethylbenzene, acetate, α-pinene and propylbenzene) (Teran et al., 2007; Dunlop et al. 2011Dunlop et al. 2011).

Accession Number:Q9WWZ9
Protein Name:TtgA
Length:384
Molecular Weight:41249.00
Species:Pseudomonas putida [303]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Lipid-anchor2
Substrate Toluene, Styrene, m-xylene, Acetate, Alpha-pinene, Propylbenzene

Cross database links:

Pfam: PF00529   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0008565 F:protein transporter activity
GO:0009306 P:protein secretion
GO:0046677 P:response to antibiotic

References (3)

[1] “Efflux pumps involved in toluene tolerance in Pseudomonas putida DOT-T1E.”  Ramos J.L.et.al.   9642183
[2] “Three efflux pumps are required to provide efficient tolerance to toluene in Pseudomonas putida DOT-T1E.”  Rojas A.et.al.   11395460
[3] “Antibiotic-dependent induction of Pseudomonas putida DOT-T1E TtgABC efflux pump is mediated by the drug binding repressor TtgR.”  Teran W.et.al.   14506010

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MQFKPAVTAL VSAVALATLL SGCKKEEAAP AAQAPQVGVV TIQPQAFTLT SELPGRTSAY 
61:	RVAEVRPQVN GIILKRLFKE GSEVKEGQQL YQIDPAVYEA TLANAKANLL ATRSLAERYK 
121:	QLIDEQAVSK QEYDDANAKR LQAEASLKSA QIDLRYTKVL APISGRIGRS SFTEGALVSN 
181:	GQTDAMATIQ QLDPIYVDVT QSTAELLKLR RDLESGQLQK AGNNAASVQL VLEDGSLFKQ 
241:	EGRLEFSEVA VDETTGSVTL RALFPNPDHT LLPGMFVHAR LKAGVNANAI LAPQQGVTRD 
301:	LKGAPTALVV NQENKVELRQ LKASRTLGSD WLIEEGLNPG DRLITEGLQY VRPGVEVKVS 
361:	DATNVKKPAG PDQANAAKAD AKAE