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3.A.1.1.22
The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins.

Accession Number:Q9X0S9
Protein Name:MalG1; aka Maltose ABC transporter, permease protein
Length:823
Molecular Weight:95232.00
Species:Thermotoga maritima [2336]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Maltose, Maltotriose, Maltotetraose, Trehalose

Cross database links:

HEGENOM: HBG617006
RefSeq: NP_229007.1   
Entrez Gene ID: 898282   
Pfam: PF00528   
BioCyc: TMAR243274:TM_1202-MONOMER   
KEGG: tma:TM1202   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.”  Nelson K.E.et.al.   10360571

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVQRRGNIFT HIFLIFIIAV ILFPVVWVVT TSLRRDEAAF SSKLFTSRLT LQHYRDLVAP 
61:	EKNLPFLVQD LQAMISKVKP YDTWSEEELK DAVESSIEKV KAYLSETETR LNDAVNSFEK 
121:	VDAFLNDHSE EIKNRTIEEM RELLSSIQIP DLSDSVENRA ALYLVLSKER YNSTAHKALK 
181:	ELLERFTGVD TGTRDGYEKA IESLKESYEK LADGYDGLIK ETQRELNAVK EEMSSLRQQY 
241:	SALQDNVMEA NLVIEKDIIP ELERIKISLS ELNNLREQIR QTALRSPFPV NDEEFSRNVS 
301:	EAVQMLNKFL NEMGSFAEYD SLKNSLVELK KELTKLSEGS EDLRNRLLFS DLVKIYEELH 
361:	PRLIRILKET AETIASIKDR IAVLNVLNER LKDLEIQEKD LTAKISEYQQ KISEVQQKLL 
421:	EPQRTLNLIV FRYELEKTIS SLERVKAFKK TDLLRYSSAL KTLRNFMNSY WKKDELYSRI 
481:	SRAVKEMRWI EEYRDFASKF DVFPENLKAI LEEMHTSLSD LERSYGDFIS LSSQGVYVSS 
541:	SVLSRMYDIV KMDFVNKVRA NMSVASRRAG NLIDLVPFSE VKKDLRNIDR ELFRIDQIWK 
601:	QKTKHYFWLW VLNSVIVSLI VAFITTTVCA IAAYPFSRMR FFGRRYGIMA LLLIQMFPGV 
661:	IFMIAIYDLL NFMGKYIPFI GIDTLGGLIF AYLTNIAYNM YLIKGFYDTI PTSLEEAAIV 
721:	DGATRFQSFY KIIIPLARPI LTVVFLLVFI GTFNEYVVAR IILQNVRHYT YALGLQAFAT 
781:	GPYETEWGLF TAAALLGMTP MVILFLSLQR YLVSGLTRGA VKE