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3.A.1.1.22
The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins.

Accession Number:Q9X103
Protein Name:MalK; aka Sugar ABC transporter, ATP-binding protein
Length:369
Molecular Weight:41539.00
Species:Thermotoga maritima [2336]
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Maltose, Maltotriose, Maltotetraose, Trehalose

Cross database links:

HEGENOM: HBG758042
RefSeq: NP_229081.1   
Entrez Gene ID: 898207   
Pfam: PF00005    PF03459   
BioCyc: TMAR243274:TM_1276-MONOMER   
KEGG: tma:TM1276   

Gene Ontology

GO:0043190 C:ATP-binding cassette (ABC) transporter complex
GO:0005524 F:ATP binding
GO:0016887 F:ATPase activity
GO:0016820 F:hydrolase activity, acting on acid anhydrid...
GO:0006810 P:transport

References (1)

[1] “Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.”  Nelson K.E.et.al.   10360571

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRMAQVVLEN VTKVYENKVV AVKNANLVVE DKEFVVLLGP SGCGKTTTLR MIAGLEEITD 
61:	GKIYIDGKVV NDVEPKDRDI AMVFQNYALY PHMTVYENMA FGLKLRKYPK DEIDRRVREA 
121:	AKILGIENLL DRKPRQLSGG QRQRVAVGRA IVRNPKVFLF DEPLSNLDAK LRVQMRSELK 
181:	KLHHRLQATI IYVTHDQVEA MTMADKIVVM KDGEIQQIGT PHEIYNSPAN VFVAGFIGSP 
241:	PMNFVNARVV RGEGGLWIQA SGFKVKVPKE FEDKLANYID KEIIFGIRPE DIYDKLFALA 
301:	PSPENTITGV VDVVEPLGSE TILHVKVGDD LIVASVNPRT QAKEEQKIDL VLDMTRMHAF 
361:	DKETEKAII