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3.A.1.1.22
The maltose, maltotriose, mannotetraose (MalE1)/maltose, maltotriose, trehalose (MalE2) porter (Nanavati et al., 2005). For MalG1 (823aas) and MalG2 (833aas), the C-terminal transmembrane domain with 6 putative TMSs is preceded by a single N-terminal TMS and a large (600 residue) hydrophilic region showing sequence similarity to MLP1 and 2 (9.A.14; e-12 & e-7) as well as other proteins.

Accession Number:Q9X2F5
Protein Name:MalG2; aka Maltose ABC transporter, permease protein
Length:833
Molecular Weight:94862.00
Species:Thermotoga maritima [2336]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Maltose, Maltotriose, Maltotetraose, Trehalose

Cross database links:

HEGENOM: HBG617006
RefSeq: NP_229633.1   
Entrez Gene ID: 897399   
Pfam: PF00528   
BioCyc: TMAR243274:TM_1836-MONOMER   
KEGG: tma:TM1836   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima.”  Nelson K.E.et.al.   10360571

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMVRKKNRWL THVLLTLLVV VVLFPIVWVV STSFRRDEAA FSPKLFSSRL TLQHYKDLVA 
61:	PEKNLPVLIQ EMQSLVSRVE PFDNVSREKA DRLIEDRIRR FENYLAETKK LLEDVNARNS 
121:	KIEETLSQRF SDVLSYTKDV LEEAKKLTQE QMDKTPLPDS QRIAVALYEK LKGKNFRSAE 
181:	FQALKDVIEK VVGYSVENQD TLNDALSELG LVYEKEVGTL MKEIEKLEGE IEILQREIAV 
241:	LEKQKETLEK EILEKQKVLE VLKPDIDSVS EVLVKLKEMV HSVRNSKVET AFPYEDSRLK 
301:	SSLEKLLSEL NTLYDKISAF SDLSDLSEKI FAMKSSLEEI NNVVSEDGDI SKKALYGSFV 
361:	QSFEETVPII EGIVEKVSDG IDDFVQKIKD LKDIENEIMV LTAKLDGLEK SLNNVRSSLS 
421:	EKEKEISSAK MYLDLKIFNH QIQSRIDSLE SMKSFNNAAQ IKLLSIYKTL KNFVSSYVSE 
481:	YGGDDFIGKI RKLAAKLSWI EDYRDLNRRI ETGYKNAVEI VEKAQNILDD FKGSYSNLLD 
541:	LSFKGLYVSS EHLEMLYDLV KMNFVQEVLT NTAVASRKAG TLMDTIPLKE LKSDLKKIDG 
601:	DLYRLAQIWE QKTKHYFLRW VMNSVIVAGL VSLITTAVCA LAAYPFSRMR FWGRQYGIMA 
661:	LLLIQMFPAI MYMVAIYGLL KLIGQFLPFL GLDSLGGLIF AYLGNIAYNM YLIKGFYDTI 
721:	PSSLEEAAMI DGATRFQTFY KIVVPLALPI LTVIVILTFI GTFNEFVLAR IILQDVKNYT 
781:	YALGLWTFST GAYETEWGLF TAAALLGMTP MVILFLSLQK YIVGGLTKGS VKG