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2.A.63.1.3
Multicomponent Na+:H+ antiporter, MnhABCDEFG

Accession Number:Q9ZNG6
Protein Name:MnhA
Length:801
Molecular Weight:89386.00
Species:Staphylococcus aureus [1280]
Number of TMSs:21
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+, H+

Cross database links:

Pfam: PF00361    PF00662   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0015077 F:monovalent inorganic cation transmembrane t...
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0042773 P:ATP synthesis coupled electron transport
GO:0030004 P:cellular monovalent inorganic cation homeos...
GO:0015992 P:proton transport
GO:0006814 P:sodium ion transport

References (2)

[1] “A putative multisubunit Na+/H+ antiporter from Staphylococcus aureus.”  Hiramatsu T.et.al.   9852009
[2] “Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host.”  Swartz T.H.et.al.   17293423

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSLLHIAVIL PLIFALIIPI LYRFFKRIHL GWFVLSVPIV IFIYMLTLIK TTMSGNTVMK 
61:	TLNWMPHFGM NFDLYLDGLG LLFSLLISGI GSLVVLYSIG YLSKSEQLGN FYCYLLLFMG 
121:	AMLGVVLSDN VIILYLFWEL TSFSSFLLIS FWRERQASIY GAQKSLIITV FGGLSLLGGI 
181:	ILLAIPTQSF SIQYMIQHAS EIQNSPFFIF AMILIMIGAF TKSAQFPFYI WLPDAMEAPT 
241:	PVSAYLHSAT MVKAGLYLIA RMTPIFAASQ GWVWTVTLVG LITLFWASLN ATKQQDLKGI 
301:	LAFSTVSQLG MIMAMLGIGA ISYHYQGDDS KIYAAAFTAA IFHLINHATF KGALFMITGA 
361:	VDHSTGTRDV KKLGGLLTIM PISFTITVIT ALSMAGVPPF NGFLSKESFL ETTFTASQAN 
421:	LFSVDTLGYL FPIIGIVGSV FTFVYSIKFI MHIFFGQYKP EQLPKKAHEV SILMLLSPAI 
481:	LATLVIVFGL FPGILTNSII EPATSSINHT VIDDVEFHMF HGLTPAFLST LVIYILGILL 
541:	IVTFSYWVKL LQRQPGKLTF NYWYNRSANV IPNYSEKMTN SYVTDYSRNN LVIIFGALIL 
601:	LTFVTIFSVP FNINFKDVSP IRIFEVCIVI LLLSAAFLIL FAKSRLFSII MLSAVGYAVS 
661:	VLFIFFKAPD LALTQFVVES ISTALFLLCF YHLPNLNRYN EKRSFQLTNA LIAGGVGLSV 
721:	IIIGLIAYGN RHFESISKFY QEHVYDLAHG KNMVNVILVD FRGMDTLFES SVLGIAGLAV 
781:	YTMIKLRKKR QTQGNEVKNH E