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1.A.1.10.10
The insect (cockroach) Na+ channel. Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites (Du et al., 2011).  Insecticides tagetting Na+ channels include indoxacarb and metaflumizone (Casida and Durkin 2013). They preferably bind to and trap sodium channels in the slow-inactivated non-conducting state, a mode of action similar to that of local anesthetics (Jiang et al. 2015).  Asp802 is involved in gating and action, but not binding, of pyrethroid insecticides (Du et al. 2010).

Accession Number:O01307
Protein Name:Para sodium channel
Length:2031
Molecular Weight:229998.00
Species:Blattella germanica (German cockroach) [6973]
Number of TMSs:22
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

Pfam: PF11933    PF00520    PF06512   

Gene Ontology

GO:0001518 C:voltage-gated sodium channel complex
GO:0005248 F:voltage-gated sodium channel activity

References (1)

[1] “A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach.”  Dong K.et.al.   9066120

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSDDSSSISE EERSLFRPFT RESLAAIEAR IAEEYAKQKE LEKKRAEGEV RYDDEDEDEG 
61:	PQPDATLEQG APIPVRMQGL FPPELASTPL EDIDPFYHNQ RTFVVVSKGK DIFRFSATDA 
121:	MWILDPFNPI RRVAIYILVH PLFSLFIITT ILTNCIFMIM PTTPTIESTE VIFTGIYTFE 
181:	SAVKVMARGF ILQPFTYLRD AWNWLDFVVI ALAYVTMGID LGNLAALRTF RVLRALKTVA 
241:	IVPGLKTIVG AVIESVKNLR DVIILTMFSL SVFALMGLQI YMGVLTQKCI KNFPINGSWG 
301:	ELNDENWHAF CSNNTNWYFP EGAPEVPLCG NSSGAGTCPP DYTCLQGFGE NPNYGYTSFD 
361:	TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN LILAIVAMSY 
421:	DELQKKAEEE EAAEEEALRE AEEAALAKEA KKLRQADKLA AQELAAAQEL AGANLAKSPS 
481:	GSSSRSYELF INQKDGNNDN KRENMSIRSE GGDSISEHKG RVGANGTAIR KVSAASLSLP 
541:	GSPFNHRRGS QGSHHFTIRN GRGRFVGPPG GDRKPLVLST YLDAQEHLPY ADDSNAVTPM 
601:	SEENGAIVVP VYYASLGSRH SSYTSHASRI SYTSHGDLLG AGNKSQTKIN QLRARSVRNN 
661:	PSQVPNSTPY MNASADSDDG AVKAKHTDNP FIEQMQQTTI VDMNDVMVLN DIIEQAAGQQ 
721:	SRASEHGVSI YYFPTDEDDE GPTVKEKVLA ICMRGIDIFC VWDCCWLWLK FQEYVALLVF 
781:	DPFVELFITL CIVVNTLFMA LDHHDMNKDM DKALKSGNYF FTATFAIEAT LKLIAMSPKY 
841:	YFQEGWNIFD FIIVALSLLE LGLEGVQGLS VLRSFRLLRV FKLAKSWPTL NLLISIMGRT 
901:	VGALGNLTFV LCIIIFIFAV MGMQLFGKNY YDNVERFPDG DMPRWNFTDF MHSFMIVFRV 
961:	LCGEWIESMW DCMLVGDWSC IPFFLATVVI GNFVVLNLFL ALLLSNFGSS NLSAPTADNE 
1021:	TNKIAEAFER FSRFFNWIKR SALNVAKMLR AKLTNQISDQ TPDAHERDTD LDLTADEILA 
1081:	DGIVYRDKKS PKEQTQLEVA IGDGMEFTIH GDLKNKLKKD KLMMNSTKVI GNSLNHKDNR 
1141:	IESGDYLHNR QDEDTLSTGS YGSHKNRPYK DDSHKGSAET MDGEEKKDAS KEDLDQEGEG 
1201:	EEDGEGEGPL EEDMVLDAGT EDVMMSEYPA DCCPDHCYKR FPFLAGDEDS PFWQGWGNLR 
1261:	LKTFQLIENK YFETAVITMI LLSSLALALE DVHLPHRPIL QDILYYMDRI FTVIFFIEML 
1321:	IKWLALGFKK YFTNAWCWLD FIIVMVSLIN FVASLVGAGG IQAFKTMRTL RALRPLRAMS 
1381:	RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYHKCVD SNSTTLSHEI 
1441:	IPDRNACIAE NYTWENSPMN FDHVGKAYLC LFQVATFKGW IQIMNDAIDS RELHKQPIRE 
1501:	TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYNAMKK 
1561:	MGSKKPLKAI PRPKWRPQAI VFEICTDKKF DMIIMLFIGF NMLTMTLDHY QQSKQFSDVL 
1621:	DYLNMIFIVI FSSECLMKIF ALRYHYFKEP WNLFDFVVVI LSILGLVLSD IIEKYFVSPT 
1681:	LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM 
1741:	HVRDKGGLDD VYNFKTFGQS MILLFQMSTS AGWDGVLDGI MNEEDCNKPN SEIGYPGDCG 
1801:	SATVGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP 
1861:	DGTQYIRYDQ LSDFLDVLEP PLQIHKPNKY KIVSMDIPIC KGDLMFCVDI LDALTKDFFA 
1921:	RKGNPIEESA ELGEVQPGRP DEVGYEPVSS TLWRQREEYC ARLIQNAWRK HKQQRQGAPG 
1981:	EDSDEAGDDP ELQDRHQTAV LVESDGFVTK NGHRVVIHSR SPSVTSRSTD V