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1.A.1.10.11
Sodium channel of 2215 aas, VmNa.  An L925V mutation in the channel domain renders the honey bee mites resistant to pyrethroids such as tau- fluvalinate and flumethrin (González-Cabrera et al. 2013).  

Accession Number:Q86D77
Protein Name:Sodium channel protein
Length:2215
Molecular Weight:248497.00
Species:Varroa destructor (honeybee mite) [109461]
Number of TMSs:17
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPPAPAETAL SANTEQPAFS TSSATPHALA LPIAEDGVHA DHDDDDFHDH DIEHMLGDEP 
61:	QSIFRPFTRE SLATQLARLA EEAAKKAQLE KMREEGIEPE PQFYHHKEAP DPDPGLEAGG 
121:	PLPKRIVNDF PPELIATPVE EIDKYYENKR TFMVISKGKD IFRFSSTNAL WILSPFNPIR 
181:	RLAICILVHP LFSFFIIVAI LVNCVLMTMP ANGKIEQTET IFTTIYTFES FIKILARGFI 
241:	LERFTYLGDP WNWLDFIVIT LAYVTMFVNL GNLSALRTFR VLRALKTVAI VPGLKTIVGA 
301:	VIESVKNLRD VIILTMFSLS VFALMGLQIY MGVLTQKCVQ QPPAGLSPPE WYDFVHNETH 
361:	WFKDSNGDFP LCGNGTGAKQ CSADYICMQG IGENPNYGFT NFDTFGWAFL SAFRLMTQDY 
421:	WESLYQMILR SAGPWHMCFF VVIIFLGSFY LVNLILAIVA MSYDDLQKRA EEEAEEDRLL 
481:	EEAMRLEEEA REEARAEAAN RVAEAKREAR EVRKDERDAA LAREMQAATA AAGGGAGKKG 
541:	VNQVPNQANH GGQLAKSPSE YSMRSLDAGT GHPSVPPDER ASLRSIDGAD LLQHTGHGGP 
601:	HSQQQQQLYS QSRHNNGKVR KASLSLPGSP FNIRRGSRSS GQWRPSGHPA NGGGGAAGRR 
661:	PGGGGGQPCY GGAKPLLRQT YVDAQEHLPF ADDSAAVTPM SEDNGAIIIP LYSNLQHSRR 
721:	SSYTSHSSRL SYTSHGEVYC LTKESQLRSR SRNLQNYFYD QETRLDSEDY ILSKIKQVNK 
781:	PYMEPSTRHP MVDMRDVMVL NDIIEQAAGR QSKASERVSI YYFSTDDEDE GSLEEEDVEA 
841:	KWKEKCLAGC LKCIDIFCVW DCCWCWIRAQ EIIGLIVFDP FMELFITLCI VVNTLFMAMD 
901:	HHDMDRDFEN VLRSGNYFFT ATFAIEATMK LMAKSPKNYF KEGWNIFDFI IVALSLLELG 
961:	LEGVQGLSVL RSFRLLRVFK LAKSWPTLNL LISIMGKTIG ALGNLTFVLG IIIFIFAVMG 
1021:	MQLFGKNYLD NKCLFPEQQV PRWNFLDFMH SLMIVFRVLC GEWIESMWDC MWVSGWPCIP 
1081:	FFLATVVIGN LVVLNLFLAL LLSSFGASNL SQANPDSGDT KKLQEAIDRF HRAGRWIKKK 
1141:	FRDLFMLCSG KQRNQISDQT YAEDLDLDTG VIIMDGQVIK KDSPTPELID GLDVGFQADK 
1201:	QQAQVIVMQK LKNNSRPIIG DSKEFSNKVH PGPDFCLVKP NDNGEGLVQD TELGASTPLS 
1261:	SPSCIVEQPL SHDSVGLPPG GQQRTTTTTA AVGGGATPAM ENNLTTPLTA GTGLTSVRFS 
1321:	GEPPNLDQHE NNPQFADATP VSLAASKDKS SGDDGDEVDG KLEGLADDVG DGGDATVSLP 
1381:	ANAEGKENAG GSDVGAEEDK EQLEGGALET AASDLIIPEL PADCCPECCY VKFACCCIFD 
1441:	DSQPLFAKYK LYRSQAFALV ENEYFETIVV VLILTSSLAL ALEDVNLKQR QWLINILNVM 
1501:	DKTFTVIFFS EMLLKWLAFG FQKYFTNAWC WLDFVIVLVS VINLVATWLG AGKIQAFKTM 
1561:	RTLRALRPLR ALSRFQGMRV VVNALVQAIP AIFNVLLVCL VFWLIFSIMG VQMFAGRFYH 
1621:	CVDANNSQLN STFIPNKEAC INNNFTWKNP MINFDNVLNA YLALFQVATF KGWTEIMAHA 
1681:	TDSRGKDDQP DYEVNIYMYL YFVFFIIFGA FFTLNLFIGV IIDNFNEQKK KAGGSLEMFM 
1741:	TEDQKKYYSA MKKMGSKKPA KAIPRPRFKL QAMIFDLTTN RMFDMAIMIF IVLNMTVMAM 
1801:	EHYQQSDFFE SILERLNIFF IAVFTAECVL KIFALRWHYF KEPWNMFDFV VVILSILGTV 
1861:	LKDLIAAYFV SPTLLRVVRV VKVGRVLRLV KGARGIRTLL FALAMSLPAL FNICLLLFLV 
1921:	MFIYAIFGMS FFMNVKHRYG VDENFNFETF GQSMILLFQM CTSAGWSDVL AAIMDETDCE 
1981:	EPTIDEDGET EGNCDKKGIA VAYLVSYLII SFLVIINMYI AVILENYSQA TEDVQEGLTD 
2041:	DDYDMYYEIW QQFDPKGTQY LPYSHLSNFV NALEEPLQIP KPNKYKLIAL DIPICKGDMV 
2101:	YCVDILDALT RDFFARKGHQ IEEPPELTEQ VIHIDRPGYE PISSTLLRQR QEYCARVIQH 
2161:	AWRRSKGEYD DSDEETGGAQ DTAIVVVDGD DTKTKVVIRP SPAPLADASR SDAQV