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1.A.1.10.13
Voltage-sensitive Na+ channel of 2821 aas and 24 TMSs (Cohen et al. 2009). Pyrethroid, an insecticide, binds to insect Na+ channels at two sites called pyrethroid,receptors, PyR1 (initial) and PyR2, located in the domain interfaces II/III and I/II, respectively, and binding residues have been identified (Du et al. 2015).

Accession Number:Q9W0Y8
Protein Name:Sodium channel protein 60E
Length:2821
Molecular Weight:318625.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:21
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDDQATFND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK 
61:	FEPFPEHMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFY PWSPARRVCV 
121:	YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY 
181:	LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR 
241:	QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRQVPTDW TNVSHTDWQI WVNDTDNWLY 
301:	DEDELPVLCG NLTGARHCPF EYVCLCVGEN PNHGYTNFDN FMWSMLTTFQ LITLDYWENV 
361:	YNMVLATCGP MSVSFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD 
421:	STFSFDPSVL NVKKLNKNNK KKIDSRKGVL LASYSKKKTR RKKTKGGKEG GTNGNGNGSN 
481:	GDDNKSHSAT PSPGPSPRHS ATERPSALTM QAQKQYQQME QQHKLAKSGS GGSNNPMAPT 
541:	PKGRISFQDS GMGVKNPNML YPSDYKGQLI ANSGQPSSNS SGVNRESSQD DSGVVDDHEE 
601:	QDTTNDMGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN 
661:	CDRCVHWCTD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL 
721:	DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL 
781:	RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTPEKF 
841:	DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF 
901:	MEVGEESKLA RSIERVRDLI RKKRQERKDR KERKFAEKFQ QIVLDAQQAH AQTLSHQAAV 
961:	GLERGDKPGV LAETKFHRLS YQESMNRPVS GSDFGFQIPL HDGLHTIVDG LEYDDTGDLP 
1021:	EQIQLQAHPL PPTSDSMPPT YESAMMATTG GSFSSVNGNG TCQNLTPFVQ AERRLQHQIS 
1081:	SGVSTQQYDS REEATYTESI ELLGQYNSTD TDPYANDQRS GCGSFNRGDS LQDNSSRRYG 
1141:	SEEHDEAFLK YQKSLLTRSP SYRKSLDRLS QSSGQSQRSL LKSEEAEMRR HSSGQSLNSM 
1201:	SIEQDELLSQ QGNLREELLN CDQKELFQFL QEEEELQKGT KLRRISNVMR SRRPSSQMGQ 
1261:	PENETMVEHS EFDNIIQSFE KELEEIKRST TSLERKLSNL SEPSPAADEA TKAIMEHIAI 
1321:	ITGASERSAA DEVVLPLNPY DSYDLSSVPR RSQSVSAAAQ RQSVKLKRRS LEKQRKIDED 
1381:	FSISNEIRKI CDQIHAPFVA MEAMAVAATS ASQAQPNQSP FLRRKVDPFT VQFDRFKRLS 
1441:	LIERVEEVPE EEKPISTLRI ESEKMPRKFL HGPDQLRLDS LSLKSTNSYE NLLIQKQKLG 
1501:	MATPPAVPAT PPTSLKSSIE PPTLAQISSL KTTPPLAALT EHQQHFHATS IQAAPTPAHT 
1561:	HAHSQAHAHS MAGQRRRMEH PQSTLDKAAS FQSARTESHS SGAADASSAL ALAMAQKTEQ 
1621:	SQSTAPDATQ KPSAFTRLTE KPWHCLVSYV DDLTVGGRRN SQGAYNDPMT FPSYGATKAA 
1681:	KVPDDCFPQK CYDHFYFRCP WFMSCMDTQS AKHWTRVRTA VLTVVDTPAF EWFVLVLIFA 
1741:	SSITLCFEDI NLDKNKTLKR VLYWINFSFC LIFVVEMILK WLALGFSKYF TSFWTILDFI 
1801:	IVFVSVFSLL IEENENLKVL RSLRTLRALR PLRAISRWQG MRIVVNALMY AIPSIFNVLL 
1861:	VCLVFWLIFS IMGVQFFGGK FFKCVNEMGE LLPITEVNDK WDCIEQNYTW INSKITFDHV 
1921:	GMGYLALLQV ATFEGWMEVM ADAVDARGVD LQPQREANLY AYIYFVIFIV CGSFFTLNLF 
1981:	IGVIIDNFNM LKKKYEGGVL EMFLTESQKH YYTAMKKLGR KKPQKVIKRP INHFLAMFYD 
2041:	LSNSRRFEIA IFVLIFLNML TMGIEHYDQP HAVFFILEVS NAFFTTVFGL EAIVKIVGLR 
2101:	YHYFTVPWNV FDFLLVLASI FGILMEDIMI DLPISPTLLR VVRVFRIGRI LRLIKAAKGI 
2161:	RKLLFALVVS LPALFNIGAL LGLITFIYAI LGMSLFGNVK LQGALDDMVN FQTFGRSMQL 
2221:	LFRLMTSAGW NDVLESLMIQ PPDCDPFIHG HTNGNCGHPL LAITYFTSFI IISYMIVINM 
2281:	YIAIILENFN QAHQEEEIGI VEDDLEMFYI RWSKYDPHAT QFIHFSQLSD FIASLDPPLG 
2341:	ISKPNNVALV SFNLPISKGN KIHCLDILHA LVKHVLGHVE ETDNFKQLQE QMDVKFKKQF 
2401:	PTRKELEIVS STRIWKRQEK AAKTIQTGWK EYLRRKREKE RSNSGDSATQ TSSPGGWQSK 
2461:	LSALNFFHLQ VSRRGTACSS RASSRKSSRA SDASDLSELA GPWLNLPLML VSGADEVVKD 
2521:	IKQQNDELGK RGSIFVEAPR ASRRRSFYNF FLRHQDAVDD SLTSPSVHRK TAMNNTTNTT 
2581:	SNSASTSGTA SSTATAPATG CGPAATSASD SDRHQAVGGG SAPSRKRASS FIRKKPPLER 
2641:	GLSAQSALRV NKNAFVSEAS APEVIVTRPS PEQQTHPHSL SLRPDNATLV HVLVHRESEE 
2701:	YKEEDESSPS VSGNGNGFGV GLDMLSKQPP PQIRITTGSV ESSMDTCAMP TVQIMVDSPK 
2761:	DPPRGDFSSA PIDDVGAPID VNVQGDTSQV FYDYNPEKAT DDQGNGQDET AQFESLPDRQ 
2821:	R