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1.A.1.10.14
The voltage-gated Ca2+ channel (VDCC; CAV2), α-subunit of 2027 aas and 24 TMSs in four domains, each with six transmembrane segments and EEEE loci in the ion-selective filter, typical of VDCCs in vertebrates. CAV2 primarily localizes in the distal part of flagella and is transported toward the flagellar tip via intraflagellar transport (IFT) although CAV2 accumulates near the flagellar base when IFT is blocked. Thus, Ca2+ influx into Chlamydomonas flagella is mediated by the VDCC, CAV2, whose distribution is biased to the distal region of the flagellum, and this is required for flagellar waveform conversion (Fujiu et al. 2009).

Accession Number:A8JF90
Protein Name:Voltage-gated Ca2+ channel, alpha subunit
Length:2027
Molecular Weight:219710.00
Species:Chlamydomonas reinhardtii [3055]
Number of TMSs:19
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTYPEYSLLF LRKSNFVRKW CVYTTHTRVF EWTILAAIIA NCVTLAVSSN RQDFDETPLG 
61:	RTLVNLEYLW VAIFTTEALL KIVAMGFVLA PGTYLRDGWN IVDFTVVALG FVDIFSSGNL 
121:	TALRTVRVLR PLRAITRIRG MRILVTTMIA ALPMLIDVFA LCAFTFFIFG LVAVQLFSGR 
181:	MTHRCAVPVF DGSYTEVVGG STFYRNVTYV VQDEESGDGC SGPMSEGLEW VDVNGTAVAL 
241:	AGGDGLGRAC PDGLYCTNYG NPNYGITSFD HILWAWLTIF QMITQEGWTD IMYFTSDTIT 
301:	WWVWPFFVAL VAFGSFYIIN LALAVLFMQF SNDNHADDPS KKKSGRQGSG DGQRQGDKAG 
361:	AGGGGAANSG GEHKDSDSES SMSDVGSEED ERLRPTMAEV TGLRTVGQHS TKLKSATSSP 
421:	LTMDEVERLS PFRRRLYRVA ASRWLELFTM SLIILNTVLM CINWFEMPES VERATNYINY 
481:	VFTVYFLVEM ILKMTAFGLV RYFRDGMNIF DCLVVVISVT EMVLDIIPSV SGLGPLSVLR 
541:	AFRLLRIFRL ARSWKELNLI IRAIFKSITS TTYLLLLMLL FMFIASLMGM QLFGYKFMFC 
601:	DYVEGAAPTC PLGWNVWGQC PDHFHCYLPC MSADYGSWVN ATGSFYNDLA YCERFCANDQ 
661:	AAAAADANAT SPDVAAAGGC EYLAMVGKSE VPRANFDNIF WSMYTVFQIL TMENWNNIMY 
721:	DGMRSTTPWC AAYFVAVVLI GTYLVFNLFV AILLDNFSSV FGESDDSDGS GSGSLKADGQ 
781:	AAGSGKHKSR RSSSSSSDTD SLHDSDLDAG EAGDAFGSMR SHCEYAGNEF ADSPHADDAS 
841:	RPSSPGGTYY STEGYHTRFS REYERAHGAG TGRGSGEGGG AGYTTHEAHA QRATGGPGGG 
901:	HAPTGASPAP QQGEGEDVAA AGGADGPGAG AGPGIGIGIG GSRRAPPTLH LPDSPSAVGA 
961:	LPPIGPAHQP VPSPKTPFSA GIGYAHPSPG AKGGHPVTQS PSDLSRGLRG VLRKVVPVDD 
1021:	EGRPGSSHSG SQPPRPSLRP VSAAPRPLSS VRGGGGNRVR PVSGRPPVKF DGVDSGREGG 
1081:	GGGGVTFAND AVSRRASFIA AHQTAAAGSQ GAGEANGGST SQGGLAASIS RSIGRSIGRS 
1141:	VSRTLQRAMS SIRSIREVRH NEHLAKQIKG RSLLLLDPEH WVRWRAARMV HHTHFETVIL 
1201:	GLIVLSSITL ALDSPGLDPD SQLAQALRYL DYIFLGAFTL EAALKIITFG FAFTGKHAYI 
1261:	RNGWNVLDFI IVLAGYALLA VELSGANGED LKMLRILRTL RALRPLRAAS RYEGLKLVVN 
1321:	TLFAVLPAMA DVALVCALFY IIFSILAVNL FKGQLYNCID ADSGERLDPY YLLPPGQTLE 
1381:	RGMCEAGSIT VNSSVYTAAR NISLMPYNIT TSWVNPVANF DNVAISMLTL FQIATLELWV 
1441:	DIMFTAVDVA GVGKQPLWNN HPVVILFFIL VVIVCCFFVL NLFIGVTLDK FTELQQAQTA 
1501:	SSVFVTPQQQ NWVDVQKLLL RTGMTSRPAR FEEPAWRAGL YDFVMGSVFE EFILITIVVN 
1561:	VLFMAMVHAD MSPQWQACMT YTNLIFTCVF VIEAALKIMA FGAFAYFRDR WNAFDFFVVV 
1621:	ISVASVVLDF SGTQNLSFMP VLRVLRVVRV VRLIRRAVGM RRLLLTLVQS LPALGNVGGV 
1681:	MVLFFFVYAV IGMNLFGGIK FGDYISRHAN FNNFGKAMLL LFRQASMARY YEARFLAVSP 
1741:	GRMITGESWS GVMQDCMITH NCVLITANVT APATNATLVE GTYLSPNDPS MSGLPPDVHQ 
1801:	NQCSLSPWAA VVYFPTFIVL CGFILLNLVI AIILENMITS ENDEGLTVSK SLVGQFVDAW 
1861:	SQVDNCATGY VHASKLPLII SHIEPPLGTR GQGNARAVTQ AVIMSVDVPI HENNTVTFVE 
1921:	TLHALAGRVA GTELPEIEEE WLVEKYSKRL PDGGAAFPKL TAAHFHAALY VQAAIRGFMA 
1981:	RHKMRGMMQT LAGGPGGAGG GTGSGSGADA DGLHNGGKAF EKGGKVA