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1.A.1.10.15
The sodium channel of 1989 aas and 24 TMSs.  80% identical to the characterized channel of the crayfish (Astacus leptodactylus (Turkish narrow-clawed crayfish) (Pontastacus leptodactylus)) in which functional regions responsible for the selectivity filter, inactivation gate, voltage sensor, and phosphorylation have been identified (Coskun and Purali 2016).

Accession Number:A1E023
Protein Name:Sodium channel protein
Length:1989
Molecular Weight:225742.00
Species:Cancer borealis (Jonah crab) [39395]
Number of TMSs:21
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPLPNRLQSS FPDDLVGVPL EDIDQFYHNR KTTVVISKGR DIFRFSATDA MWILSPFNPV 
61:	RRTAMFILIH PLFNFFIICT ILANCVLMIM PTNETIESSE VLFTAIYTFE SGVKVMARGF 
121:	ILESFTYLRD AWNWLDFTVI SLAYVTMGID LGNLAALRTF RVLRALKTVA IVPGLKTIVG 
181:	AVIESVKNLR DVIILTVFSL SVFALLGLQI YMGVLTQKCI RKFDFTKENW TLDDVENFYM 
241:	NQSNWLKDEG VQDSPLCGNS SGAGTCPHNY ICRQGYGPSP NYGYTNFDSF GWSFLSAFRL 
301:	MTQDYWENLY QLVLRSAGPW HIIFFVVIIF LGSYYLVNLI LAIVAMSYDQ LQKKAEEEEE 
361:	AALAEEEELK AREEKELADT QRALDLAAGL EDGGSMINSP SVYSGDTYEN YNSTDQGGDD 
421:	TMKDASIRSE EQDSRGRHNG KRKASISLPG SPYNPRRGSR SSHQCTWRTS NGRRFGDRKP 
481:	LVLSTYMDAM EHLPYADDSN AVTPMSEENG AIIVPVYTTL GSRHNSYTSH TSRISYTSHG 
541:	DLLNGKPPTT KASKLLNRSP RNMNTSLPPE LDNNMLQMLP LRPEGEAMRR KEDEVIDNII 
601:	REIFGPDITL EYIDKDASAQ ATPLARSKEN VVEDSDDMLA LKLKNPDANP FIDPIQKQTV 
661:	VDMRDVRVLQ DIIEQAAVNA GRMSRASDHG VSIYYFSAEE EEESFKEKLK KKLLEYLLKA 
721:	IDIFCVWDCC SYWNKFAKLV ELLVFDPFVE LFITLCIVVN TLFMAMDHYG MNCSFDHFLK 
781:	MGNYFFTATF SIECFLKIIA MSPKYYLQEG WNIFDFIIVF LSLLELGLAN VSGLSVLRSF 
841:	RLLRVFKLAK SWPTLNLLIS IMGKTVGALG NLTFVLCIII FIFAVMGMQL FGKNYTEKVM 
901:	KFPPNPDGQL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MLVCGYSCIP FFMATVIIGN 
961:	LVVLNLFLAL LLSSFGASNL SAPPSDGDTN KLSEAFERIA RFKAWVKRTV FNVLKHVRAK 
1021:	LTNQISDQTP DGRDLEGEDI LMDGQTGNKK LPKDHTQVDI PMDGFDLPDG KMKNNTVINN 
1081:	KYIGNSVSLD NRDVAIIEND YGNNKKAKRL EEDALSNNSL GSHRHHKLKS DSGSHKGSTE 
1141:	TVDDGEEKRD ASKEDFDDDH GGSGDEGELE EEEGEDVGPV VDTGSNAALD YPSDCFKEGC 
1201:	YTRWPFCAGD PESPFWQGWG HLRLKTYQLI ENKYFETAVI TMILLSSLAL AAEDVNLKGR 
1261:	PALQDILYYM DRIFTVIFFI EMLIKWVALG FSKYFTNAWC WLDFLIVMVS LINLVATLAG 
1321:	GGKIQAFKTM RTLRALRPLR ALSRMQGMRV VVNALVGAIP SIVNVLLVCL IFWLIFAIMG 
1381:	VQLFNGRYHK CIDAEGLKLN AEIVPDRLMC LYMNYSWVNS EVHFDHVGMA YLALFQVATW 
1441:	KGWIQIMNDA IDSTQLEKQP MREVNINMYM YFVFFIIFGS FFTLNLFIGV IIDNFNEQKK 
1501:	KAGGSLEMFM TDDQKKYYNA MKKMGGKKPL KAIPRPQFRP QAVVFEIVTS KKFDMIIMIF 
1561:	IGMNMLTMTM DHYQMTETWK MGLNYLNLIF ICIFTSECVL KVFALRWHYF KEPWNLYDFV 
1621:	VVIMSILGMV LKDIIEKYFV SPTLLRVVRV AKVGRVLRLV KGAKGIRTLL FALAMSLPAL 
1681:	FNICLLLFLV MYISAIYGMS FFMNVKHTGG LDSVYNFETF FQSFILLFQM MTSAGWDGVL 
1741:	SGIVNEKNCK PPNPEVGDPG DCGNQAIGIA YLLGYLVISF LIVINMYIAV ILENYSQATE 
1801:	DVEEGLTDDD YDMYYEIWQQ FDPKGTQYIL FAQVSDFLDV LEAPLQIHKP NKYKIVSMDI 
1861:	TICKGDLVFC VDVLDALTKD FFARKGNPVE DSADMGDVGP PQDRPGYEPV SSTLWRQREE 
1921:	YCARLIQQAW RRHRQHKDQS SLSGGESQEE LKQADTAVLV ESDGYVTKNG HKVVIHSRSP 
1981:	SLTSRSTDV