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1.A.1.10.16
The voltage-gated sodium channel of 2147 aas and 24 TMSs.  Several mutations in the structural gene give rise to pyrethroid resistance (kdr) (Saavedra-Rodriguez et al. 2007).

Accession Number:C3RTM3
Protein Name:Sodium channel protein
Length:2147
Molecular Weight:240913.00
Species:Aedes aegypti (Yellowfever mosquito) [7159]
Number of TMSs:22
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTEDSDSISE EERSLFRPFT RESLAAIERR IADAEAKQRE LEKKRAEGET GFGRKKKKKE 
61:	IRYDDEDEDE GPQPDSTLEQ GVPIPVRMQG SFPPELASTP LEDIDSYYAN QRTFVVVSKG 
121:	KDIFRFSATN ALYVLDPFNP IRRVAIYILV HPLFSFFIIT TILTNCILMI MPSTPTVEST 
181:	EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT 
241:	FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC 
301:	IREFPMDGSW GNLSDENWER FNNNDSNWYF SETGDTPLCG NSSGAGQCEE GYICLQGYGD 
361:	NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN 
421:	LILAIVAMSY DELQKRAEEE EAAEEEALRE AEEAAAAKAA KLEAQAAAAA AAANPEIAKS 
481:	PSDFSCHSYE LFVNQEKGND DNNKEKMSIR SEGLESVSEI TRTTAPTATA AGTAKARKVS 
541:	AGVAAFQKAS LSLPGSPFNL RRGSRGSHQF TIRNGRGRFV GVPGSDRKPL VLSTYLDAQE 
601:	HLPYADDSNA VTPMSEENGA IIVPVYYANL GSRHSSYTSH QSRISYTSHG DLLGGMTKES 
661:	RLRNRSARNT NHSIVPPPNM SGPNMSYVDS NHKGQRDFDM SQDCTDEAGK IKHNDNPFIE 
721:	PSQTQTVVDM KDVMVLNDII EQAAGRHSRA SDHGVSVYYF PTEDDDEDGP TFKDKALEFT 
781:	MRMIDVFCVW DCCWVWLKFQ EWVAFIVFDP FVELFITLCI VVNTLFMALD HHDMDPDMER 
841:	ALKSGNYFFT ATFAIEATMK LIAMSPKYYF QEGWNIFDFI IVALSLLELG LEGVQGLSVL 
901:	RSFRLLRVFK LAKSWPTLNL LISIMGRTMG ALGNLTFVLC IIIFIFAVMG MQLFGKNYID 
961:	NVDRFPDKDL PRWNFTDFMH SFMIVFRVLC GEWIESMWDC MLVGDVSCIP FFLATVVIGN 
1021:	LVGLNLFLAL LLSNFGSSSL SAPTADNETN KIAEAFNRIS RFSNWIKSNI ANALKFVKNK 
1081:	LTSQIASVQP AGEQHNHLSW IWNEGKGVCP CISAEHGENE LELTPDDILA DGLLKKGVKE 
1141:	HNQLEVAIGD GMEFTIHGDL KNKGKKNKQL MNNSKVIGNS ISNHQDNKLE HELNHRGMSL 
1201:	QDDDTASIKS YGSHKNRPFK DESHKGSAET MEGEEKRDVS KEDLGIDEEL DDECDGEEGP 
1261:	LDGELIIHAD EDEVIEDSPA DCCPDNCYKK FPVLAGDDDA PFWQGWANLR LKTFQLIENK 
1321:	YFETAVITMI LLSSLALALE DVHLPHRPIL QDVLYYMDRI FTVIFFLEML IKWLALGFRV 
1381:	YFTNAWCWLD FIIVMVSLIN FVASLCGAGG IQAFKTMRTL RALRPLRAMS RMQGMRVVVN 
1441:	ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL FAGKYFKCVD KNKTTLSHEI IPDVNACVAE 
1501:	NYTWENSPMN FDHVGKAYLC LFQVATFKGW IQIMNDAIDS REVGKQPIRE TNIYMYLYFV 
1561:	FFIIFGSFFT LNLFIGVIID NFNEQKKKAG GSLEMFMTED QKKYYNAMKK MGSKKPLKAI 
1621:	PRPRWRPQAI VFEIVTNKKF DMIIMLFIGF NMLTMTLDHY KQTDTFSAVL DYLNMIFICI 
1681:	FSSECLMKIF ALRYHYFIEP WNLFDFVVVI LSILGLVLSD LIEKYFVSPT LLRVVRVAKV 
1741:	GRVLRLVKGA KGIRTLLFAL AMSLPALFNI CLLLFLVMFI FAIFGMSFFM HVKYKSGLDD 
1801:	VYNFKTFGQS MILLFQMSTS AGWDGVLDGI INEDECLPPD NDKGYPGNCG SATIGITYLL 
1861:	AYLVISFLIV INMYIAVILE NYSQATEDVQ EGLTDDDYDM YYEIWQQFDP DGTQYIRYDQ 
1921:	LSDFLDVLEP PLQIHKPNKY KIISMDIPIC RGDMMFCVDI LDALTKDFFA RKGNPIEETA 
1981:	ELGEVQARPD EVGYEPVSST LWRQREEYCA RVIQHAWRKH KERQAGGGGG DDTDADACDN 
2041:	DDGDDGGGGA GDGGSAGGGG VTSPGVGSGS IVGGGTTPGS GGGGSQANLG IVVEHNLSPK 
2101:	ESPDGNNDPQ GRQTAVLVES DGFVTKNGHR VVIHSRSPSI TSRSADV