TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.1.10.17
Voltage-gated Na+ Channel protein of 2,139 aas and 24 TMSs.  Mediates voltage-dependent sodium ion permeability of excitable membranes.  3-d modeling revealed spacial clustering of evolutionarily conserved acidic residues at extracellular sites (Vinekar and Sowdhamini 2016).

Accession Number:A5I843
Protein Name:Sodium channel protein
Length:2139
Molecular Weight:240085.00
Species:Anopheles gambiae (African malaria mosquito) [7165]
Number of TMSs:21
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MTEDSDSISE EERSLFRPFT RESLQAIEAR IADEEAKQRE LERKRAEGES DFGRKKKKKE 
61:	IRYDDEDEDE GPQPDPTLEQ GVPVPVRMQG SFPPELASTP LEDIDSFYSN QRTFVVISKG 
121:	KDIFRFSATN ALYVLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST 
181:	EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT 
241:	FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC 
301:	IKEFPLDGSW GNLTDESWEL FNSNDTNWFY SESGDIPLCG NSSGAGQCDE GYICLQGYGK 
361:	NPNYGYTSFD TFGWAFLSAF RLMTQDYWEN LYQLVLRSAG PWHMLFFIVI IFLGSFYLVN 
421:	LILAIVAMSY DELQKKAEEE EAAEEEALRE AEEAAAAKAA KLEAQQAAAA AAANPEIAKS 
481:	PSDFSCHSYE LFVGQEKGND DNNKEKMSIR SEGLESVSEI TRTTAPTATA AGTAKARKVS 
541:	AGVATIQKAS LSLPGSPFNL RRGSRGSHQF TIRNGRGRFV GVPGSDRKPL VLSTYLDAQE 
601:	HLPYADDSNA VTPMSEENGA IIVPVYYANL GSRHSSYTSH QSRISYTSHG DLLGGMTKES 
661:	RLRNRSARNT NHSIVPPPNA NNLSYAETNH KGQRDFDLTQ DCTDDAGKIK HNDNPFIEPA 
721:	QTQTVVDMKD VMVLNDIIEQ AAGRHSRASD HGVSVYYFPT EDDDEDGPTF KDKALEFLMK 
781:	MIDIFCVWDC CWVWLKFQEW VAFIVFDPFV ELFITLCIVV NTLFMALDHH DMDPDMEKAL 
841:	KSGNYFFTAT FAIEATMKLI AMSPKYYFQE GWNIFDFIIV ALSLLELGLE GVQGLSVLRS 
901:	FRLLRVFKLA KSWPTLNLLI SIMGRTMGAL GNLTFVLCII IFIFAVMGMQ LFGKNYVDNV 
961:	DRFPDHDLPR WNFTDFMHSF MIVFRVLCGE WIESMWDCML VGDVSCIPFF LATVVIGNLV 
1021:	VLNLFLALLL SNFGSSSLSA PTADNETNKI AEAFNRISRF SNWIKMNLAN ALKFVKNKLT 
1081:	SQIASVQPTG KGVCPCISSE HGENELELTP DDILADGLLK KGIKEHNQLE VAIGDGMEFT 
1141:	IHGDLKNKAK KNKQIMNNSK VIGNSISNHQ DNKLDHELNH RGVSLQDDDT ASIKSYGSHK 
1201:	NRPFKDESHK GSAETMEGEE KRDASKEDLG IDEELDDEGE GDEGPLDGEL IIHAEEDEVI 
1261:	EDSPADCCPD NCYKKFPVLA GDDDAPFWQG WGNLRLKTFQ LIENKYFETA VITMILLSSL 
1321:	ALALEDVHLP QRPILQDILY YMDRIFTVIF FLEMLIKWLA LGFKVYFTNA WCWLDFIIVM 
1381:	VSLINFVASL CGAGGIQAFK TMRTLRALRP LRAMSRMQGM RVVVNALVQA IPSIFNVLLV 
1441:	CLIFWLIFAI MGVQLFAGKY FKCVDKNKTT LPHEIIPDVN ACKAENYSWE NSPMNFDHVG 
1501:	KAYLCLFQVA TFKGWIQIMN DAIDSRDVGK QPIRETNIYM YLYFVFFIIF GSFFTLNLFI 
1561:	GVIIDNFNEQ KKKAGGSLEM FMTEDQKKYY NAMKKMGSKK PLKAIPRPRW RPQAIVFEIV 
1621:	TNKKFDMIIM LFIGFNMLTM TLDHYKQSET FSAVLDYLNM IFICIFSSEC LMKIFALRYH 
1681:	YFIEPWNLFD FVVVILSILG LVLSDIIEKY FVSPTLLRVV RVAKVGRVLR LVKGAKGIRT 
1741:	LLFALAMSLP ALFNICLLLF LVMFIFAIFG MSFFMHVKDK SGLDDVYNFK TFGQSMILLF 
1801:	QMSTSAGWDG VLDGIINEED CLPPDNDKGY PGNCGSSTIG ITYLLAYLVI SFLIVINMYI 
1861:	AVILENYSQA TEDVQEGLTD DDYDMYYEIW QQFDPDGTQY VRYDQLSDFL DVLEPPLQIH 
1921:	KPNRYKIISM DIPICRGDMM FCVDILDALT KDFFARKGNP IEETAELGEV QQRPDEVGYE 
1981:	PVSSTLWRQR EEYCARLIQH AWKRYKQRHG GGTDASGDDL EIDACDNGCG GGNGNENDDS 
2041:	GDGATGSGDN GSQHGGGSIS GGGGTPGGGK SKGIIGSTQA NIGIVDSNIS PKESPDSIGD 
2101:	PQGRQTAVLV ESDGFVTKNG HRVVIHSRSP SITSRTADV