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1.A.1.10.18
Sodium channel protein, α-subunit, FPC1, of 2050 aas and 24 TMSs.  The 3-d structure has been solved by cryoEM to 3.8 Å resolution (Shen et al. 2017). One residue at the corresponding selectivity filter (SF) locus in each repeat, Asp/Glu/Lys/Ala (DEKA), determines Na+ selectivity. The S1 to S4 segments in each repeat form a voltage-sensing domain (VSD), wherein S4 carries repetitively occurring positive residues essential for voltage sensing. There are seven extracellular glycosylation sites (Shen et al. 2017).

Accession Number:D0E0C1
Protein Name:Sodium channel protein
Length:2050
Molecular Weight:232057.00
Species:Periplaneta americana (American cockroach) [6978]
Number of TMSs:24
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSDDSSSISE EERSLFRPFT RESLAAIEAR IAEEYAKRKE LEKKRAEGEG DSGRKRKKKE 
61:	VRYDDEDEDE GPQPDATLEQ GAPIPVRMQG LFPPELASTP LEDIDPFYQN QRTFVVVSKG 
121:	KDIFRFSATE AMWILDPFNP IRRVAIYILV HPLFSLFIIT TILTNCIFMI MPTTPTIEST 
181:	EVIFTGIYTF ESAVKVMARG FILQPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT 
241:	FRVLRALKTV AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC 
301:	VKNFPSDGSW GNLTDENWFS FCSNKSHWYI PDDTIEYPLC GNSSGAGTCP PGYTCLQGFG 
361:	DNPNYGYTSF DTFGWAFLSA FRLMTQDYWE NLYQLVLRSA GPWHMLFFIV IIFLGSFYLV 
421:	SLILAIVAMS YDELQKKAEE EEAAEEEALR EAEEAARAKE AKRARQADKE AAHAAGLAQA 
481:	AAEVVKSPSG SSCLSYELFV GQKGNADNNK EKMSIRSEEG DSISEHRRIV GANGTAGVRK 
541:	VSAASLSLPG SPFNLRRGSR GSHQFPIRNG RGRFVGPPGG DRKPLVLSTY LDAQEHLPYA 
601:	DDSNAVTPMS EENGAIVVPV YYANLGSRHS SYTSHASRIS YTSHGDLLGA GGKPRTKESQ 
661:	LRTRSGRNNP SQLPNSTPYM SDDHKYMDAS VDSDDGAVKA KHSDNPFIEQ MQQTTIVDMN 
721:	DVMVLNDIIE QAAGRQSRAS EQGDEDDEGP TVKEKVLAIC LRGIDIFCVW DCCWLWLKFQ 
781:	EYVALLVFDP FVELFITLCI VVNMLFMALD HYDMNKDMEK ALKSGNYFFT ATFAIEATLK 
841:	LIAMSPKYYF QEGWNIFDFI IVALSLLELG LEGVQGLSVL RSFRLLRVFK LAKSWPTLNL 
901:	LISIMGRTVG ALGNLTFVLC IIIFIFAVMG MQLFGKNYFD NVERFPDGDT PRWNFADFMH 
961:	SFMIVFRVLC GEWIESMWDC MLVGDWSCIP FFLATVVIGN LVVLNLFLAL LLSNFGSSNL 
1021:	SAPTADNETN KIAEAFDRFS RLFNWIKRSA LSVAKMLRAK LTNQISDQTP GEGPSSSWKE 
1081:	DAHDRDTDLD LTADEIIADG MVYRDKKSPK DQTQLEVAIG DGMEFTIHGD LKNKLKEDKL 
1141:	LMNNTKVIGN SFQGNHKDNR IENDYLHNRQ DEDTLSTRSY GSHKNRPFKD ESHKGSAETM 
1201:	DGEGKKDASK EDLEQEGNAE EDGEGEEGHL EEDMALDGGT EDVMMSEYPA DCCPEKCYRR 
1261:	FPFLAGDEDS PFWQGWGNLR LKTFQLIENK YFETAVITMI LLSSLALALE DVHLSYRPIL 
1321:	QDILYYMDRI FTVIFFIEML IKWLALGFKK YFTNAWCWLD FVIVMVSLIN FVASLVGAGG 
1381:	IQAFKTMRTL RALRPLRAMS RMQGMRVVVN ALVQAIPSIF NVLLVCLIFW LIFAIMGVQL 
1441:	FAGKYHKCVD GNSTTLSHEI IPDRNACIAE NYTWENSPMN FDHVGKAYLC LFQVATFKGW 
1501:	IQIMNDAIDS RDLFKQPIRE TNIYMYLYFV FFIIFGSFFT LNLFIGVIID NFNEQKKKAG 
1561:	GSLEMFMTED QKKYYNAMKK MGSKKPLKAI PRPKWKPQAI VFEICTNKKF DMIIMLFIGF 
1621:	NMLTMTLDHY QQSQQFSDVL DYLNMIFIVI FSSECLMKIF ALRYHYFKEP WNLFDFVVVI 
1681:	LSILGLVLSD IIEKYFVSPT LLRVVRVAKV GRVLRLVKGA KGIRTLLFAL AMSLPALFNI 
1741:	CLLLFLVMFI FAIFGMSFFM HVRDKGGLDD VYNFKTFGQS MILLFQMSTS AGWDGVLDGI 
1801:	MNEDDCRKPD NELGYPGNCG SATIGIAFLL SYLVISFLIV INMYIAVILE NYSQATEDVQ 
1861:	EGLTDDDYDM YYEIWQQFDP DGTQYIRYDQ LSEFLDVLEP PLQIHKPNKY KIVSMDIPIC 
1921:	KGDLMFCVDI LDALTKDFFA RKGNAIDESG ELGEVQARPD EVGYEPVSST LWRQREEYCA 
1981:	RLIQNAWRKH KQQRQGGPGE DSDDAGDDAD LHDRHQTAVL VESDGFVTKN GHRVVIHSRS 
2041:	PSVTSRSTDV