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1.A.1.10.20
Voltage-gated sodium channel of 1836 aas and 24 TMSs, PaFPC1. The 3-d structure has been determined (Shen et al. 2017).  It mediates the voltage-dependent sodium ion permeability in excitable membranes.

Accession Number:D0E0C2
Protein Name:Sodium channel protein PaFPC1
Length:1553
Molecular Weight:179116.00
Species:Periplaneta americana (American cockroach) [6978]
Number of TMSs:21
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADNSPLIRE ERQRLFRPYT RAMLTAPSAQ PAKENGKTEE NKDNSRDKGR GANKDRDGSA 
61:	HPDQALEQGS RLPARMRNIF PAELASTPLE DFDPFYKNKK TFVVVTKAGD IFRFSGEKSL 
121:	WMLDPFTPIR RVAISTMVQP IFSYFIMITI LIHCIFMIMP ATQTTYILEL VFLSIYTIEV 
181:	VVKVLARGFI LHPFAYLRDP WNWLDFLVTL IGYITLVVDL GHLYALRAFR VLRSWRTVTI 
241:	VPGWRTIVDA LSLSITSLKD LVLLLLFSLF VFAVLGLQIY MGVLTQKCVK HFPADGSWGN 
301:	FTDERWFNYT SNSSHWYIPD DWIEYPLCGN SSGAGMCPPG YTCLQGYGGN PNYGYTSFDT 
361:	FGWAFLSVFR LVTLDYWEDL YQLALRSAGP WHILFFIIVV FYGTFCFLNF ILAVVVMSYT 
421:	HMVKRADEEK AAERELKKEK KAASVANNTA NGQEQTTIEM NGDEAVVIDN NDQAARQQSD 
481:	PETPAPSVTQ RLTDFLCVWD CCVPWQKLQG AIGAVVLSPF FELFIAVIIV LNITFMALDH 
541:	HDMNIEFERI LRTGNYIFTS IYIVEAVLKI IALSPKFYFK DSWNVFDFII VVFAILELGL 
601:	EGVQGLSVFR SFRLLRVFRL AKFWPTLNNF MSVMTKSYGA FVNVMYVMFL LLFIFAIIGM 
661:	QLFGMNYIDN MERFPDGDLP RWNFTDFLHS FMIVFRALCG EWIESMWDCM LVGDWSCIPF 
721:	FVAVFFVGNL VILNLLIALL LNNYGSFCTS PTSDEEDSKD EDALAQIVRI FKRFKPNLNA 
781:	VKLSPMKPDS EDIVESQEIQ GNNIADAEDV LAGEFPPDCC CNAFYKCFPS RPARDSSVQR 
841:	MWSNIRRVCF LLAKNKYFQK FVTAVLVITS VLLALEDIYL PQRPVLVNIT LYVDYVLTAF 
901:	FVIEMIIMLF AVGFKKYFTS KWYWLDFIVV VAYLLNFVLM CAGIEALQTL RLLRVFRLFR 
961:	PLSKVNGMQV VTSTLVEAVP HIFNVILVGI FFWLVFAIMG VQLFAGKFYK CVDENSTVLS 
1021:	HEITMDRNDC LHENYTWENS PMNFDHVGNA YLSLLQVATF KGWLQIMNDA IDSREVHKQP 
1081:	IRETNIYMYL YFIFFIVFGS FFILKLFVCI LIDIFRQQRR KAEGLSATDS RTQLIYRRAV 
1141:	MRTMSAKPVK RIPKPTCHPQ SLMYDISVNR KFEYTMMILI ILNVAVMAID HYGQSMEFSE 
1201:	VLDYLNLIFI IIFFVECVIK VSGLRHHYFK DPWNIIDFLY VVLAIAGLML SDVIEKYFIS 
1261:	PTLLRILRIL RVGRLLRYFQ SARGMRLLLL ALRKALRTLF NVSFLLFVIM FVYAVFGMEF 
1321:	FMHIRDAGAI DDVYNFKTFG QSIILLFQLA TSAGWDGVYF AIANEEDCRA PDHELGYPGN 
1381:	CGSRALGIAY LVSYLIITCL VVINMYAAVI LDYVLEVYED SKEGLTDDDY DMFFEVWQQF 
1441:	DPEATQYIRY DQLSELLEAL QPPLQVQKPN KYKILSMNIP ICKDDHIFYK DVLEALVKDV 
1501:	FSRRGSPVEA GDVQAPNVDE AEYKPVSSTL QRQREEYCVR LIQNAWRKHK QQN