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1.A.1.11.12
T-type Ca2+ channel (Cav3.1d) in developing heart (fetal myocardium (Cribbs et al., 2001). Both Cav3.1 and Cav3.2 are permeated by divalent metal ions, such as Fe2+ and Mn2+, and possibly Cd2+ (Thévenod, 2010).  CaV3.1 channels are activated at low votage and regulate neuronal excitability in the spinal cord (Canto-Bustos et al. 2014).  It is regulated by protein kinase C (PKC) and the RanBPM protein (acc# Q96S59) (Kim et al. 2009).

Accession Number:Q9WUT2
Protein Name:Voltage-gated calcium channel, alpha-1-G subunit aka Cav3.1d
Length:2295
Molecular Weight:253960.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:16
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q9WUT2
RefSeq: NP_001106284.1    NP_033913.2   
Entrez Gene ID: 12291   
Pfam: PF00520   
KEGG: mmu:12291   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity
GO:0006816 P:calcium ion transport
GO:0060371 P:regulation of atrial cardiomyocyte membrane...
GO:0002027 P:regulation of heart rate
GO:0010045 P:response to nickel ion
GO:0055085 P:transmembrane transport

References (1)

[1] “A T-type calcium channel from mouse brain.”  Klugbauer N.et.al.   10087148

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MDEEEDGAGA EESGQPRSFT QLNDLSGAGG RQGPGSTEKD PGSADSEAEG LPYPALAPVV 
61:	FFYLSQDSRP RSWCLRTVCN PWFERVSMLV ILLNCVTLGM FRPCEDIACD SQRCRILQAF 
121:	DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR 
181:	TVRVLRPLRA INRVPSMRIL VTLLLDTLPM LGNVLLLCFF VFFIFGIVGV QLWAGLLRNR 
241:	CFLPENFSLP LSVDLEPYYQ TENEDESPFI CSQPRENGMR SCRSVPTLRG EGGGGPPCGL 
301:	DYEAYNSSSN TTCVNWNQYY TNCSAGEHNP FKGAINFDNI GYAWIAIFQV ITLEGWVDIM 
361:	YFVMDAHSFY NFIYFILLII VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA 
421:	STLASFSEPG SCYEELLKYL VYILRKAARR LAQVSRAVGV RAGLLSSPVA RGGQEPQPSG 
481:	SCSRSHRRLS VHHLVHHHHH HHHHYHLGNG TLRVPRASPE IQDRDANGSR WLMLPPPSTP 
541:	TPSGGPPRGA ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE 
601:	MLKDKALVEV APSPGPPTLT TFNIPPGPFS SMHKLLETQS TGACHSSCKI SSPCSKADSG 
661:	ACGPDSCPYC ARTGAGEPES ADHEMPDSDS EAVYEFTQDA QHSDLRDPHR RRRPSLGPDA 
721:	EPSSVLAFWR LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI 
781:	VFTSLFALEM LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR 
841:	VLKLVRFLPA LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL 
901:	PDRKNFDSLL WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV 
961:	AILVEGFQAE EIGKREDTSG QLSCIQLPVN SQGGDATKSE SEPDFFSPSV DGDGDRKKRL 
1021:	ALVALGEHSE LRKSLLPPLI IHTAATPMSL PKSSSTGVGE ALGSGSRRTS SSGSAEPGTA 
1081:	HHEMKSPPSA RSSPHSPWSA ASSWTSRRSS RNSLGRAPSL KRRSPSGERR SLLSGEGQES 
1141:	QDEEESSEED RASPAGSDHR HRGSLEREAK SSFDLPDTLQ VPGLHRTASG RSSASEHQDC 
1201:	NGKSASGRLA RTLRADDPPL DGDDGDDEGN LSKGERLRAW VRARLPACCR ERDSWSAYIF 
1261:	PPQSRFRLLC HRIITHKMFD HVVLVIIFLN CITIAMERPK IDPHSAERIF LTLSNYIFTA 
1321:	VFLAEMTVKV VALGWCFGEQ AYLRSSWNVL DGLLVLISVI DILVSMVSDS GTKILGMLRV 
1381:	LRLLRTLRPL RVISRAQGLK LVVETLMSSL KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF 
1441:	VCQGEDTRNI TNKSDCAEAS YRWVRHKYNF DNLGQALMSL FVLASKDGWV DIMYDGLDAV 
1501:	GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL NMFVGVVVEN FHKCRQHQEE EEARRREEKR 
1561:	LKRLEKKRRS KEKQMADLML DDVIASGSSA SAASEAQCKP YYSDYSRFRL LVHHLCTSHY 
1621:	LDLFITGVIG LNVVTMAMEH YQQPQILDEA LKICNYIFTV IFVLESVFKL VAFGFRRFFQ 
1681:	DRWNQLDLAI VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL 
1741:	LDTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLECDE THPCEGLGRH ATFRNFGMAF 
1801:	LTLFRVSTGD NWNGIMKDTL RDCDQESTCY NTVISPIYFV SFVLTAQFVL VNVVIAVLMK 
1861:	HLEESNKEAK EEAELEAELE LEMKTLSPQP HSPLGSPFLW PGVEGVNSPD SPKPGAPHTT 
1921:	AHIGAASSGF SLEHPTMVPH TEEGPVPLGP DLLTVRKSGV SRTHSLPNDS YMCRNGSTAE 
1981:	RSLGHRGWGL PKAQSGSILS VHSQPADTSC ILQLPKDAHY LLQPHGAPTW GAIPKLPPPG 
2041:	RSPLAQRPLR RQAAIRTDSL DVQGLGSRED LLSEVSGPSC PLTRSSSFWG GSSIQVQQRS 
2101:	GSQSKVSKHI RLPAPCPGLE PSWAKDPQET RSSLELDTEL SWISGDLLPS SQEEPLSPRD 
2161:	LKKCYSVEAQ SCRRRPGSWL DEQRRHSIAV SCLDSGSQPR LCPSPSSLGG QPLGGPGSRP 
2221:	KKKLSPPSIS IDPPESQGPR PPCSPGVCLR RRAPASDSKD PSASSPLDST AASPSPKKDA 
2281:	LSLSGLSSDP TDLDP