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1.A.1.11.13
Two-pore Ca2+ channel protein 1, TPC1 (Km(Ca2+))=50 ┬ÁM; voltage gated; 461 aas; 6TMSs) (Hashimoto et al., 2004; Kurusu et al, 2004; 2005)

Accession Number:Q5QM84
Protein Name:Two pore calcium channel protein 1 aka TPC1
Length:757
Molecular Weight:87069.00
Species:Oryza sativa subsp. japonica (Rice) [39947]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

HEGENOM: HBG591069
RefSeq: NP_001043858.1   
Entrez Gene ID: 4325272   
Pfam: PF00520   
KEGG: osa:4325272   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0005509 F:calcium ion binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0006952 P:defense response
GO:0055085 P:transmembrane transport

References (6)

[1] “Functional analysis of a rice putative voltage-dependent Ca2+ channel, OsTPC1, expressed in yeast cells lacking its homologous gene CCH1.”  Hashimoto K.et.al.   15111725
[2] “Identification of a putative voltage-gated Ca2+ -permeable channel (OsTPC1) involved in Ca2+ influx and regulation of growth and development in rice.”  Kurusu T.et.al.   15215504
[3] “The genome sequence and structure of rice chromosome 1.”  Sasaki T.et.al.   12447438
[4] “The map-based sequence of the rice genome.”  International rice genome sequencing project (IRGSP)et.al.   16100779
[5] “Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana.”  The rice annotation project (RAP)et.al.   17210932
[6] “Identification of a putative voltage-gated Ca2+ channel as a key regulator of elicitor-induced hypersensitive cell death and mitogen-activated protein kinase activation in rice.”  Kurusu T.et.al.   15941394

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRERGEMREA KAPLIAEAAE HISHSHGSGS SGTGSHTSGG GGGWRGSRQY QRRSDALAYG 
61:	NRYQKAAALV DLAEDGVGIP EDVLNDTRFE RAMRFYFVYL RLDWLWSLNL FALILLNFLE 
121:	KPLWCRGYSQ HACDQRDLYF LGQLPYLSKT ESLIYEGLTL VILVMDIFYP LSYEGLNLFW 
181:	KNTINKLKVL LLFILACDIL VFAFSPQPFR VAPYIRVAFL IMNIRELRMC AVTLVGMVGT 
241:	YLNVLALSLL FLLFASWLAY VTFEDTPQGK TVFSSYGTTL YQMFILFTTS NNPDVWVPAY 
301:	KSSRWSSLFF IVYVLLGVYF LTNLILAVIY DSFKEQLAKQ VSQADCTRKS ILEKAFGIID 
361:	ATGQGYLNKE QCLSLLDELN KYRSLPKTSR EDFELIFAEL DQSGDFKVTS EEFATLCNTI 
421:	AIKFQKEPPP SYLEKYPSFY HSALCEWLKS FVRSPLFEYI VIFVLLMNLV AVIIETTLDI 
481:	ENSSSQKVWQ EVEFVFGWIY VIEMALKIFS LGFGAYWMEG QNKFDFVLTW TIFIGETLTF 
541:	AFPSKLSFLS NGEWIRYLLL GRMLRLTRIL LQVRRFRAFV ATFFTLMSSL MPYLGIVFCT 
601:	LCIYCSLGLQ IFGGIVYAGN PTLEETDLFS NDYLLFNFND YPSGMVTLFN LLVMGNWQAW 
661:	MESYRQLTGS YWSLIYFVSF YLISVLLLLN LIVAFVLEAF FAEMELEKDG EADIQDPTLE 
721:	GRNRRRSVRV RTKGTMVDIL LHHMLSNELD GSQNRDQ