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1.A.1.11.16
4 domain-type voltage-gated ion channel, α-1 subunit NCA-2 (Jospin et al., 2007) (dependent on Unc-80 (3225aas; CAB042172) for proper localization).

Accession Number:Q06AY4
Protein Name:NCA-2
Length:1763
Molecular Weight:203754.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:23
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

eggNOG: meNOG06369
RefSeq: NP_001129835.1   
Entrez Gene ID: 175674   
Pfam: PF00520   
KEGG: cel:C27F2.2   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.”  Humphrey J.A.et.al.   17350263
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLTRRKSSID GTKTERNRRR GESIGGAFTD MINIEPTSII NKSTELLHER FLRDMVRVAC 
61:	LLSMISLCLH TPETIKMWPP LNYIILANDV IVTLIFIGEA AVTINQNGLF DNQNSYLRDR 
121:	WYQFEFFLLI NHILSCVIHI YELCSIWFPA LNFVYYPWLG ALRSARPFIF LRFIRSIVRF 
181:	KLPKNRIKLI IKRSSQQIQN VTIFFMFFVF SYAIMGVQLF GRLNYHCVVN GTDPNNVTIA 
241:	DLAIPDTMCS QKGAGGYECP GNMVCMRLQL KPQEEGFYGQ FSDFASSLFT VYLAASQEGW 
301:	VYVLYDCLDS LPSFLAFFYF VTLIFFLAWL VKNVFIAVIT ETFAEIRVQF SEMWQTREAT 
361:	TDHVYTQKLE KDEDGWKLVE VDKYNRAHSN NSLFLHTIVT STAFQTVMQL LILANAIFHA 
421:	TFVFYHDESD QIRKIWYYYV EVGFTILFNT EVIIKIYAFG WKAYIARGQH KFDCILCVGS 
481:	SLNAIWVLYE TNIFTYFQVF RIARLIKASP MLEDFVYKIF GPGKKLGGLV IFTGILLIVT 
541:	SAISLQLFCY VPKLNKFTNF AVAFMSMFQI ITQEGWTDVV IEILRACNEQ AVPFVAIYFV 
601:	AYHLLVTLFV LSLFVAVILD NLEMDEELKK VKQLKAREQD TIKTTLPMRL RIFNRFPTAP 
661:	TMVTMKKVSS EFPLPKIRDS FTRQFADEFV ETSDDTIQEI GFKVRSMLSG RGPSKETRIT 
721:	TTIRHVGQLS NKTILTSMLT ESNRNRALFS ESNQHLASLT RSNTSSKHGK SGALSTNSRS 
781:	RTRGLASLKG KHMVEGFKEN GDLRPEDTAR KVEKHGEIDF KALQMKRAHA EITRNRIEEE 
841:	MRENHPMFDR PLFLVGRESS LRRMCQLIAH SRHSYDQNDG QHRKHSNKYK QFHDFLAIMT 
901:	YMDWTMVLVT TLSCCSMLWE SPWPTTGENL IFNNFYLQIA EYIFVLVMSF ELIVKCIANG 
961:	LFFTPKALVT DVGDILTIFI YITSLMFLIW MPNHIEINSW AQLLMVCRAM RPLRVYALIP 
1021:	HIRRVVVELC RGFREILLVT ILLVVLMFIF ASFGVQLVGG KLASCNDPMI TSRENCTGLY 
1081:	DVKLFVTRME VYGKNDNLMH PSIIVPRVWT NPRNFNFDHI GNAMLALFET LSYKGWNVVR 
1141:	DVLYLRHGAW AVLFIHIYVF IGCMIGLTLF VGVVVANYTE NRGTALLTVD QRRWHDLKAR 
1201:	LKMAQPLHVP PKPPESAKLR CYLYDLTTSR WFKQLFAVLV VVNSFTLVIP WNVSEEQDRK 
1261:	TFLLCLTVIS AICNILFTLE CLLKMIAFTL SGFWQSRRNR IDFIITILGI NWIVFHFLFQ 
1321:	LPAYFAGGIT EWKRLTYTYG YLVVILRFFT IAGRKSTLKM LMLTVVMSMV RSSFIIAAMF 
1381:	LLVLFYANAG VVLFGMVKYG QAVGKHVNFR NGREALVVLF RSVTGEDWND IMHDCMRAPP 
1441:	FCNWHPGLSY WQTDCGNYVG AIVYFCSFYL IITYIVLNLL VAIIMENFSL FYSSEEDALL 
1501:	SYADIRNFQL VWNMVDIEQK RSIPVRRVKF LLRLLKGRLE VNDESDGLLF KHMCHEMERL 
1561:	HNGDDVSFHD VLNMLSYRSV DIRKSLQLEE LLQREELEYI IEEEVAKHTI RAWLENCLKN 
1621:	IKAKQNNTLG KMSSIGSTFA FPQSQEVLTK GVVLTEASPE EDSLQGDKGS GKKKAQRGNS 
1681:	ITEIVAEAQK KSVKRATDKI SERRGTLRQM QMGTYDELEE VEEDEDTDGE IRRSSFEYSG 
1741:	VDMIQMSHEK QLEDVKTWWT LCD