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1.A.1.11.20
The voltage-gated Ca2+ channel, L-type α-subunit, Eg1-19 regulated by Macoilin (8.A.38.1.2)

Accession Number:A8PYS5
Protein Name:Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog
Length:1879
Molecular Weight:214983.00
Species:Brugia malayi (Filarial nematode worm) [6279]
Number of TMSs:19
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Entrez Gene ID: 6102794   
Pfam: PF08763    PF00520   
KEGG: bmy:Bm1_39550   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity

References (1)

[1] “Draft genome of the filarial nematode parasite Brugia malayi.”  Ghedin E.et.al.   17885136

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MASSTEEDDH HAEDPHKSDL WQQTLQAAVA ATSQSEAAKK RQQQRKPMRQ NNVVERSERS 
61:	LLCLTLSNPL RKACITIVEW RPFEWLILLM ICANCIALAV YQPYPAQDSD TKNIILEQIE 
121:	YLFIVVFTIE CVLKVIALGF LFHPGAYLRN AWNILDFIIV VIGLVSTALS RMNIQGFDVK 
181:	ALRAFRVLRP LRLVSGVPSL QVVLNAILRA MIPLLHIALL VMFVIIIYAI IGLELFCGKL 
241:	HSTCFDPTTG ELAQHTPSTC GFASSAFHCQ PNGHYEGVHW VCTSNTSWQG PNNGITNFDN 
301:	FGLAMLTVFQ CVSLEGWTDV MYWVNDAVGR EWPWIYFVTL VILGSFFVLN LVLGVLSGEF 
361:	SKEREKARAR GLFQKFREKQ QLEEDLKGYL DWINQAEDIE PVNDDEQEDE QQFNGEELDE 
421:	ETDEKTDDSR PSWWKKRLRR MQKLNRRCRR GCRRLVKSQT FYWLVIVLVL LNTLVLTTEH 
481:	YKQEPWLDHF QTVANLFFVI LFSMEMILKM YSLGLTTYTT SQFNRFDCFV VISSIVEFVL 
541:	VYFDLMKPLG VSVLRSARLL RIFKVTKYWT SLRNLVSSLL NSLRSIMSLL LLLFLFIVIF 
601:	ALLGMQVFGG KFNFNPMNPK PRANFDTFIQ ALLTVFQILT GEDWNTVMYN GIASFGGVGS 
661:	WGVLVSVYFI VLFICGNYIL LNVFLAIAVD NLADADSLTN AEKEEEQAEV EEEVAEDDYE 
721:	DEKYDENGNE ETRDDSRIVM EEEEEGGEII TARPRRMSEL VTAKQQKPIP KASSLFILSH 
781:	TNPFRVFCNK IVNHSYFTNS VLICILVSSA MLAAEDPLEA QSPRNTILNY FDYFFTTVFT 
841:	VEITLKVVVY GLMFHKGSFC RNAFNLLDIL VVAVSLVSFV LKSDAISVVK ILRVLRVLRP 
901:	LRAINRAKGL KHVVQCVIVA VKTIGNIMLV TFMLQFMFAI IGVQLFKGTF FRCTDESKMT 
961:	EYECRGEFLA YEDGDPMKPL RMRREWIKND FNFDNVGDAM ISLFVVSTFE GWPDLLYVAI 
1021:	NSNEEDHGPV YNARQAVAIF FITFIVVIAF FMMNIFVGFV IVTFQNEGER EYENCELDKN 
1081:	QRKCIEFALK AKPHRRYIPR NRFQYRVWWF VTSQFFEYVI FIIILLNTTT LAMKHYPPDP 
1141:	GMDHVLDVLN LIFTGVFALE AVFKIIALNP KNYFGDRWNA FDFVIVLGSF IDIIYGKLSP 
1201:	GSNIISINFF RLFRVMRLVK LLSRGEGIRT LLWTFMKSFQ ALPYVALLIV LLFFIYAVIG 
1261:	MQVFGKVALN DETHIHRNNN FHTFPAAVLV LFRSATGEAW QEIMLSCSDR DEVKCDPASD 
1321:	DYKQNPDAKC GVDFAYPYFI SFFMLCSFLV INLFVAVIMD NFDYLTRDWS ILGPHHLEEF 
1381:	VRLWSEYDPD AKGRIKHLDV VTLLRKISPP LGFGKLCPHR LACKRLVSMN MPLNSDGTVC 
1441:	FNATLFALVR TNLKIYTEGN IDEVNEQLRS AIRRIWKRTP QKMLDEVVPP AGRDDDVTVG 
1501:	KFYATFLIQD YFRRFKKRKE LESKGIVPQQ TSQAMALQAG LRTLHEIGPE LKRAISGNLE 
1561:	TDFTLDVEEP QHRRPHSLFN NIISALGGSA RANQIYREDR TTRSLSMTAN NQLSPTRSLY 
1621:	GNNDMVSVTA HGHLTSNCSI NIPPSARSNG GVLQRRLPQI PSPNISFNQK LLENDLLVSR 
1681:	LALNAESHYI LANRSMPLDT DEEEEWGERR DTNRLRNDET WMNNGRPGKG LRKPFMLARN 
1741:	QAMAIAGVPA DISEAFEGTY RPAPDGKSVR LPLSNRPVLR PDRNEEGLTG RLVGEALALG 
1801:	RYMDERVVEA ARREIAEAYS LEESELESAA ATLADARYME HLGMERCEVR DFNRYSARAL 
1861:	LRPAPSQEAP EDDLFITTL