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1.A.1.11.21
Voltage-gated Ca2+ channel, Egl-19, isoform a

Accession Number:G5EG02
Protein Name:Protein EGL-19, isoform a
Length:1783
Molecular Weight:202591.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:18
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Entrez Gene ID: 177513   
Pfam: PF08763    PF00520   
KEGG: cel:C48A7.1   

Gene Ontology

GO:0005891 C:voltage-gated calcium channel complex
GO:0005245 F:voltage-gated calcium channel activity

References (2)

[1] “Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans.”  Lee R.Y.N.et.al.   9321386
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSVLASMMSS GEDEEQAAAD EQERTDLWQQ TLQAAVAASS SQDATKKRPA QRKPLRQTNV 
61:	VERSERSLLC LSLNNPIRKL CISIVEWKPF EFLILFMICA NCIALAIYQP YPAQDSDYKN 
121:	TLLETIEYVF IVVFTIECVL KIVAMGFMFH PSAYLRNAWN ILDFIIVVIG LVSTILSKMS 
181:	IQGFDVKALR AFRVLRPLRL VSGVPSLQVV LNAILRAMIP LLHIALLVLF VILIYAIIGL 
241:	ELFCGKLHST CIDPATGQLA QKDPTPCGTD TEGSAFKCQP SDSLTNMGVR WECSSNTTWP 
301:	GPNNGITNFD NFGLAMLTVF QCVSLEGWTD VMYWVNDAVG REWPWIYFVT LVILGSFFVL 
361:	NLVLGVLSGE FSKEREKARA RGLFQKFREK QQLEEDLKGY LDWITQAEDI EPVNEDEQED 
421:	EPVAQTVVGE EADEEGEERV EDVRPSKWAA RMKRLEKLNR RCRRACRRLV KSQTFYWLVI 
481:	LLVLLNTLVL TSEHYGQSEW LDHFQTMANL FFVILFSMEM LLKMYSLGFT TYTTSQFNRF 
541:	DCFVVISSIL EFVLVYFDLM KPLGVSVLRS ARLLRIFKVT KYWTSLRNLV SSLLNSLRSI 
601:	ISLLLLLFLF IVIFALLGMQ VFGGKFNFNP QQPKPRANFD TFVQALLTVF QILTGEDWNT 
661:	VMYHGIESFG GVGTLGVIVC IYYIVLFICG NYILLNVFLA IAVDNLADAD SLTNAEKEEE 
721:	QQEIEGEDEE FEEGEDEGEE HGMDEPEGDE EMTSARPRRM SEVPAASTVK PIPKASSLFI 
781:	LSHTNSFRVF CNMVVNHSYF TNAVLFCILV SSAMLAAEDP LQANSTRNMI LNYFDYFFTS 
841:	VFTVEITLKV IVFGLVFHKG SFCRNAFNLL DILVVAVSLT SFVLRTDAMS VVKILRVLRV 
901:	LRPLRAINRA KGLKHVVQCV IVAVKTIGNI MLVTFMLQFM FAIIGVQLFK GTFFLCNDLS 
961:	KMTEAECRGE YIHYEDGDPT KPVSKKRVWS NNDFNFDNVG DAMISLFVVS TFEGWPQLLY 
1021:	VAIDSNEEDK GPIHNSRQAV ALFFIAFIIV IAFFMMNIFV GFVIVTFQNE GEREYENCEL 
1081:	DKNQRKCIEF ALKAKPHRRY IPRNRLQYRV WWFVTSRAFE YVIFLIIVMN TVSLACKHYP 
1141:	SSRGFEDFLD VFNLIFTGVF AFEAVLKIVA LNPKNYISDR WNVFDLLVVV GSFIDITYGK 
1201:	LNPGGTNLIS INFFRLFRVM RLVKLLSRGE GIRTLLWTFM KSFQALPYVA LLIVLLFFIY 
1261:	AVIGMQFFGK VALDDSTSIH RNNNFHSFPA AILVLFRSAT GEAWQDIMLS CSDREDVRCD 
1321:	PMSDDYHKGG LNESRCGNNF AYPYFISFFM LCSFLVINLF VAVIMDNFDY LTRDWSILGP 
1381:	HHLEEFVRLW SEYDPDAKGR IKHLDVVTLL RKISPPLGFG KLCPHRLACK RLVSMNMPLN 
1441:	SDGTVCFNAT LFALVRTNLK IYTEGNIDEA NEQLRSAIKR IWKRTHKDLL DEVVPPAGKE 
1501:	DDVTVGKFYA TFLIQDYFRR FKKRKEMEAK GVLPAQTPQA MALQAGLRTL HEIGPELKRA 
1561:	ISGNLETDFN FDEPEPQHRR PHSLFNNLVH RLSGAGSKSP TEHERIEKGS TLLPFQPRSF 
1621:	SPTHSLAGAE GSPVPSQMHR GAPINQSINL PPVNGSARRL PALPPYANHI HDETDDGPRY 
1681:	RDTGDRAGYD QSSRMVVANR KYADARIVGA ARREIEEAYS LGEQEIDLAA DSLAPLMQHV 
1741:	GMHDIRDINE NSRSALLRPA ENSSRQHDSR GGSQEDLLLV TTL