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1.A.1.12.1
Paramecium bursaria Chlorella virus 1 (PBCV-1) K+ channel, Kcv1. (The viral-encoded K+ channel inserts into the green algal host membrane to aid ejection of DNA from the viral particle into the cytoplasm (Neupartl et al., 2007)). It may mediate host cell membrane depolarization and K+ loss (Agarkova et al., 2008; Balss et al., 2008).  It is inhibited by Ba2+ and amantidine. (Reviewed by Thiel et al., 2010). The presence of charged amino acids which form dynamic inter- and intra- subunit salt bridges is crucial for channel activity (Hertel et al. 2010).

Accession Number:Q84568
Protein Name:A250R protein
Length:94
Molecular Weight:10620.00
Species:Paramecium bursaria Chlorella virus 1 (PBCV-1) [10506]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

RefSeq: NP_048599.1   
Entrez Gene ID: 918298   
Pfam: PF07885   

Gene Ontology

GO:0005216 F:ion channel activity

References (4)

[1] “Analysis of 94 kb of the chlorella virus PBCV-1 330-kb genome: map positions 88 to 182.”  Lu Z.et.al.   8614977
[2] “Chlorella virus PBCV-1 encodes a functional homospermidine synthase.”  Kaiser A.et.al.   10544099
[3] “Characterization of a beta-1,3-glucanase encoded by chlorella virus PBCV-1.”  Sun L.et.al.   11021991
[4] “Small potassium ion channel proteins encoded by chlorella viruses.”  Kang M.et.al.   14762169

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLVFSKFLTR TEPFMIHLFI LAMFVMIYKF FPGGFENNFS VANPDKKASW IDCIYFGVTT 
61:	HSTVGFGDIL PKTTGAKLCT IAHIVTVFFI VLTL