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1.A.1.12.2
Acanthocystis turfacea chlorella virus cation, K+-preferring, channel, ATCV1 (82aas) (Gazzarrini et al., 2009; Siotto et al. 2014). The difference in open probability between close isoforms is caused by one long closed state in KcvS versus KcvNTS. This state is structurally created in the tetrameric channel by a transient, Ser mediated, intrahelical hydrogen bond. The resulting kink in the inner transmembrane domain swings the aromatic rings from downstream Phenylalanines in the cavity of the channel, which blocks ion flux.

Accession Number:A7K9J5
Protein Name:Putative uncharacterized protein Z585R
Length:82
Molecular Weight:9035.00
Species:Acanthocystis turfacea Chlorella virus 1 [322019]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Early endosome membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

RefSeq: YP_001427066.1   
Entrez Gene ID: 5470584   
Pfam: PF07885   

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLLLIIHIII LIVFTAIYKM LPGGMFSNTD PTWVDCLYFS ASTHTTVGYG DLTPKSPVAK 
61:	LTATAHMLIV FAIVISGFTF PW