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1.A.1.13.2
2 TMS ( P-loop) Ca2+-gated K+ channel, MthK (see Jiang et al., 2002 for the crystal structure, and Parfenova et al., 2006 for mutations affecting open probability). For the studies of ion permeation and Ca2+ blockage, see Derebe et al., 2011. (structures: 3LDD_A and 2OGU_A.). Voltage-dependent K+ channels including MthK which lacks a canonical voltage sensor can undergo a gating process known as C-type inactivation, which involves entry into a nonconducting state through conformational changes near the channel's selectivity filter (Thomson and Rothberg, 2010). C-type inactivation may involve movements of transmembrane voltage sensor domains.  

Accession Number:O27564
Protein Name:Calcium-gated potassium channel MthK
Length:336
Molecular Weight:37314.00
Species:Methanobacterium thermoautotrophicum [187420]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: arNOG11331
DIP: DIP-46253N
RefSeq: NP_276634.1   
Entrez Gene ID: 1471789   
Pfam: PF07885    PF02080    PF02254   
BioCyc: MTHE187420:MTH1520-MONOMER   
KEGG: mth:MTH1520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0003824 F:catalytic activity
GO:0008324 F:cation transmembrane transporter activity
GO:0005216 F:ion channel activity
GO:0046872 F:metal ion binding
GO:0008152 P:metabolic process
GO:0006813 P:potassium ion transport

References (2)

[1] “Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics.”  Smith D.R.et.al.   9371463
[2] “Crystal structure and mechanism of a calcium-gated potassium channel.”  Jiang Y.et.al.   12037559
Structure:
1LNQ   2AEF   2AEJ   2AEM   2FY8   2OGU   3KXD   3LDC   3LDD   3LDE   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MVLVIEIIRK HLPRVLKVPA TRILLLVLAV IIYGTAGFHF IEGESWTVSL YWTFVTIATV 
61:	GYGDYSPSTP LGMYFTVTLI VLGIGTFAVA VERLLEFLIN REQMKLMGLI DVAKSRHVVI 
121:	CGWSESTLEC LRELRGSEVF VLAEDENVRK KVLRSGANFV HGDPTRVSDL EKANVRGARA 
181:	VIVDLESDSE TIHCILGIRK IDESVRIIAE AERYENIEQL RMAGADQVIS PFVISGRLMS 
241:	RSIDDGYEAM FVQDVLAEES TRRMVEVPIP EGSKLEGVSV LDADIHDVTG VIIIGVGRGD 
301:	ELIIDPPRDY SFRAGDIILG IGKPEEIERL KNYISA