TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.1.14.4
Voltage-gated Na+ channel, VGSC (Koishi et al., 2004; McCusker et al., 2011) Changing the selectivity filter from LESSM to LDDWSD yielded a Calcium-selective channel (Shaya et al., 2011).

Accession Number:Q6TMY8
Protein Name:SPO0030
Length:258
Molecular Weight:28970.00
Species:Silicibacter pomeroyi [89184]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+

Cross database links:

HEGENOM: HBG320980
RefSeq: YP_165303.1   
Entrez Gene ID: 3195038   
Pfam: PF00520   
BioCyc: RPOM246200:SPO_0030-MONOMER   
KEGG: sil:SPO0030   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005248 F:voltage-gated sodium channel activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “A prokaryotic voltage-gated sodium channel.”  Ren D.et.al.   11743207
[2] “Genome sequence of Silicibacter pomeroyi reveals adaptations to the marine environment.”  Moran M.A.et.al.   15602564

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQRMQAFIDR PGFGRFITAV IMLNAVVLGM ETSPYLMERW GGLILAADRI CLGIFIVEIA 
61:	LKLTAQRQRF FLNGWNLFDF VIVGIALIPA AGGLSVLRAL RILRVLRVIS VAPRLRRVVE 
121:	GFITALPGMA SVFLLMTIIF YIGAVIATKL FAASFPDWFG DLGLSAYTLF QIMTLESWSM 
181:	GIVRPVMQVY PYAWLFFVPF IMITTFAVVN LLVGLIVNSM QDAHHAEDGE RTDAYRDEVL 
241:	ARLEQIDQRL NALGETKK