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1.A.1.14.5
Voltage-gated Na+ channel, NavCh. 3d-structure known (3ROW; Payandeh et al., 2011). An anionic coordination site was proposed to confer Na+ selectivity through partial dehydration of Na+ via its direct interaction with conserved glutamate side chains. The pore is preferentially occupied by two ions, which can switch between different configurations by crossing low free-energy barriers (Furini and Domene, 2012).

Accession Number:A8EVM5
Protein Name:Ion transport protein
Length:267
Molecular Weight:31071.00
Species:Arcobacter butzleri (strain RM4018) [367737]
Number of TMSs:5
Substrate Na+

Cross database links:

eggNOG: COG1226
HEGENOM: HBG320980
DIP: DIP-59168N
Entrez Gene ID: 5624115   
Pfam: PF00520   
KEGG: abu:Abu_1752   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005216 F:ion channel activity

References (2)

[1] “The complete genome sequence and analysis of the Epsilonproteobacterium Arcobacter butzleri.”  Miller W.G.et.al.   18159241
[2] “The crystal structure of a voltage-gated sodium channel.”  Payandeh J.et.al.   21743477
Structure:
3RVY   3RVZ   3RW0   4EKW   4MS2   4MTF   4MTG   4MTO   4MVM   4MVO   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MYLRITNIVE SSFFTKFIIY LIVLNGITMG LETSKTFMQS FGVYTTLFNQ IVITIFTIEI 
61:	ILRIYVHRIS FFKDPWSLFD FFVVAISLVP TSSGFEILRV LRVLRLFRLV TAVPQMRKIV 
121:	SALISVIPGM LSVIALMTLF FYIFAIMATQ LFGERFPEWF GTLGESFYTL FQVMTLESWS 
181:	MGIVRPLMEV YPYAWVFFIP FIFVVTFVMI NLVVAIIVDA MAILNQKEEQ HIIDEVQSHE 
241:	DNINNEIIKL REEIVELKEL IKTSLKN