1.A.1.14.6
Bacterial voltage-gated sodium channel, Nav. The 3-d crystal structure of the open-channel conformation is known (McCusker et al. 2012). It has its internal cavity accessible to the cytoplasmic surface as a result of a bend/rotation about a central residue in the carboxy-terminal TMS that opens the gate to allow entry of hydrated sodium ions. The molecular dynamics of ion transport through the open conformation has been analyzed (Ulmschneider et al. 2013). The C-terminal four helix coiled coil bundle domain couples inactivation with channel opining, depedent on the negatively charged linker region (Bagnéris et al. 2013).
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Accession Number: | A0L5S6 |
Protein Name: | Ion transport protein |
Length: | 274 |
Molecular Weight: | 30909.00 |
Species: | Magnetococcus sp. (strain MC-1) [156889] |
Number of TMSs: | 4 |
Substrate |
Na+ |
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1: MSRKIRDLIE SKRFQNVITA IIVLNGAVLG LLTDTTLSAS SQNLLERVDQ LCLTIFIVEI
61: SLKIYAYGVR GFFRSGWNLF DFVIVAIALM PAQGSLSVLR TFRIFRVMRL VSVIPTMRRV
121: VQGMLLALPG VGSVAALLTV VFYIAAVMAT NLYGATFPEW FGDLSKSLYT LFQVMTLESW
181: SMGIVRPVMN VHPNAWVFFI PFIMLTTFTV LNLFIGIIVD AMAITKEQEE EAKTGHHQEP
241: ISQTLLHLGD RLDRIEKQLA QNNELLQRQQ PQKK