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1.A.1.14.6
Bacterial voltage-gated sodium channel, Nav.  The 3-d crystal structure of the open-channel conformation is known (McCusker et al. 2012).  It has its internal cavity accessible to the cytoplasmic surface as a result of a bend/rotation about a central residue in the carboxy-terminal TMS that opens the gate to allow entry of hydrated sodium ions. The molecular dynamics of ion transport through the open conformation has been analyzed (Ulmschneider et al. 2013).  The C-terminal four helix coiled coil bundle domain couples inactivation with channel opining, depedent on the negatively charged linker region (Bagnéris et al. 2013).

Accession Number:A0L5S6
Protein Name:Ion transport protein
Length:274
Molecular Weight:30909.00
Species:Magnetococcus sp. (strain MC-1) [156889]
Number of TMSs:4
Substrate Na+

Cross database links:

Structure:
3ZJZ   4CBC   4F4L   4OXS   4P2Z   4P30   4P9O   4P9P   4PA3   4PA4   [...more]

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSRKIRDLIE SKRFQNVITA IIVLNGAVLG LLTDTTLSAS SQNLLERVDQ LCLTIFIVEI 
61:	SLKIYAYGVR GFFRSGWNLF DFVIVAIALM PAQGSLSVLR TFRIFRVMRL VSVIPTMRRV 
121:	VQGMLLALPG VGSVAALLTV VFYIAAVMAT NLYGATFPEW FGDLSKSLYT LFQVMTLESW 
181:	SMGIVRPVMN VHPNAWVFFI PFIMLTTFTV LNLFIGIIVD AMAITKEQEE EAKTGHHQEP 
241:	ISQTLLHLGD RLDRIEKQLA QNNELLQRQQ PQKK