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1.A.1.14.7
Tetrameric 6 TMS subunit Na+ channel protein, NaV.  Two low resolution cyroEM structures revealed two conformations reconstituted in lipid bilayers (Tsai et al. 2013). Despite a voltage sensor arrangement identical with that in the activated form, Tsai et al. 2013 observed two distinct pore domain structures: a prominent form with a relatively open inner gate, and a closed inner-gate conformation similar to the first prokaryotic Nav structure. Structural differences, together with mutational and electrophysiological analyses, indicated that widening of the inner gate was dependent on interactions among the S4-S5 linker, the N-terminal part of S5 and its adjoining part in S6, and on interhelical repulsion by a negatively charged C-terminal region subsequent to S6 (Tsai et al. 2013).

Accession Number:F5L478
Protein Name:Ion transport protein
Length:298
Molecular Weight:34442.00
Species:Caldalkalibacillus thermarum TA2.A1 [986075]
Number of TMSs:5
Substrate Na+

Cross database links:

Structure:
4BGN     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSHIHERHSQ LKHPIEAWCD WLVNHPRFTS AIIVLIVINA IVVGMETYPG IYQPYQDWFY 
61:	LIDRMILWVF TAEIILKLVA TRPRYHFFKD SWNVFDFLIV ASGHLFVGAQ FVTVLRVLRV 
121:	LRLLRAVTVI PSLRRLVSAL LYTIPSLGNI MLLMGLIFYI FGVMGTFLFR DVAPEYFGSL 
181:	HLSLITLFQV VTLESWASGI MRPIMAEVFW SWIYFVAFIL VGTFVIFNLF VGVIVSNVER 
241:	AETEDAEQEE GQREERQGLF EGDGSSVSAE EIAKLRQEIK ELRQLLKELK DHHSQSST