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1.A.1.14.8
Voltage-gated Na+ channel, Nsv, of 277 aas and 6 TMSs with a structually defined C-terminal regulatory domain (Miller et al. 2016). Voltage-gated sodium channels (NaVs) are activated by transiting the voltage sensor from the deactivated to the activated state. Tang et al. 2017 identified peptide toxins stabilizing the deactivated VSM of bacterial NaVs. A cystine knot toxin, called JZTx-27, from the venom of the tarantula Chilobrachys jingzhao proved to be a high-affinity antagonist. JZTx-27 stabilizes the inactive form of the voltage sensor, thereby inhibiting channel activity (Tang et al. 2017).

Accession Number:J8TM36
Protein Name:Potassium ion channel transporter
Length:277
Molecular Weight:31949.00
Species:Bacillus alcalophilus ATCC 27647 = CGMCC 1.3604 [1218173]
Number of TMSs:5
Substrate Na+

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FASTA formatted sequence
1:	MQKQSLLIHF SKKIVSHRYF TRIIITLILF NALLVGLETY PALRHEYGSL FHVLDVILLW 
61:	IFTLEILTRF LATTPKKDFF KGGWNWFDTI IVLSSHIFVG GHFITVLRIL RVLRVLRAIS 
121:	VIPSLRRLVD ALMLTIPALG NILILMSIIF YIFAVLGTML FANVAPEYFA NLQLSMLTLF 
181:	QIVTLDSWGS GVMRPILVDI PWAWTYFIAF VLVGTFIIFN LFIGVIVNNV EKANEDEVKD 
241:	KVKEKEEAAQ KQMDSLHEEL KEIKQYLKSI EKQNRSS