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1.A.1.18.1
The two-pore domain potassium channel, TRESK-1 (Czirjak et al., 2004) (provides the background K+ current in mouse DRG neurons (Dobler et al., 2007)) TRESK (TWIK-related spinal cord K+ channel) is reversibly activated by the calcium/calmodulin-dependent protein phosphatase, calcineurin, and Czirjak et al. (Czirjak et al. 2008) reported that 14-3-3 proteins which directly bind to the intracellular loop to TRESK and control the kinetics of the calcium-dependent regulation. Cloxyquin (5-chloroquinolin-8-ol) is an activator (Wright et al. 2013).  A cytoplasmic loop binds tubulin (Enyedi et al. 2014).

Accession Number:Q6VV64
Protein Name:TRESK-1
Length:394
Molecular Weight:44403.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q6VV64
eggNOG: roNOG13077
HEGENOM: HBG444618
RefSeq: NP_997144.1   
Entrez Gene ID: 332396   
Pfam: PF07885   
KEGG: mmu:332396   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015269 F:calcium-activated potassium channel activity
GO:0006813 P:potassium ion transport

References (5)

[1] “The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.”  Czirjak G.et.al.   14981085
[2] “Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.”  Keshavaprasad B.et.al.   16192517
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.”  Czirjak G.et.al.   16569637

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAEEPPEAR RCCPEALGKA RGCCPEALGK LLPGLCFLCC LVTYALVGAA LFSAVEGRPD 
61:	PEAEENPELK KFLDDLCNIL KCNLTVVEGS RKNLCEHLQH LKPQWLKAPQ DWSFLSALFF 
121:	CCTVFSTVGY GHMYPVTRLG KFLCMLYALF GIPLMFLVLT DIGDILATIL SRAYSRFQAL 
181:	LCLPHDIFKW RSLPLCRKQP DSKPVEEAIP QIVIDAGVDE LLNPQPSKDP PSPSCNVELF 
241:	ERLVAREKKN KLQPPTRPVE RSNSCPELVL GRLSCSILSN LDEVGQQVER LDIPLPVIAL 
301:	VVFAYISCAA AILPFWETEL GFEDAFYFCF VTLTTIGFGD IVLVHPHFFL FFSIYIIVGM 
361:	EILFIAFKLM QNRLLHTYKT LMLFVCQREV SLPW