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1.A.1.18.1
The two-pore domain potassium channel, TRESK-1 (Czirjak et al., 2004) (provides the background K+ current in mouse DRG neurons (Dobler et al., 2007)) TRESK (TWIK-related spinal cord K+ channel) is reversibly activated by the calcium/calmodulin-dependent protein phosphatase, calcineurin. Czirjak et al. 2008 reported that 14-3-3 proteins directly bind to the intracellular loop to TRESK and control the kinetics of the calcium-dependent regulation. Cloxyquin (5-chloroquinolin-8-ol) is an activator (Wright et al. 2013).  A cytoplasmic loop binds tubulin (Enyedi et al. 2014). Channel activity is modified by phosphorylation (inactive) and dephosphorylation (active) of the unusually long intracellular loop between the 2nd and 3rd TMS (Lengyel et al. 2018).

Accession Number:Q6VV64
Protein Name:TRESK-1
Length:394
Molecular Weight:44403.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q6VV64
eggNOG: roNOG13077
HEGENOM: HBG444618
RefSeq: NP_997144.1   
Entrez Gene ID: 332396   
Pfam: PF07885   
KEGG: mmu:332396   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015269 F:calcium-activated potassium channel activity
GO:0006813 P:potassium ion transport

References (5)

[1] “The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin.”  Czirjak G.et.al.   14981085
[2] “Species-specific differences in response to anesthetics and other modulators by the K2P channel TRESK.”  Keshavaprasad B.et.al.   16192517
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Targeting of calcineurin to an NFAT-like docking site is required for the calcium-dependent activation of the background K+ channel, TRESK.”  Czirjak G.et.al.   16569637

External Searches:

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEAEEPPEAR RCCPEALGKA RGCCPEALGK LLPGLCFLCC LVTYALVGAA LFSAVEGRPD 
61:	PEAEENPELK KFLDDLCNIL KCNLTVVEGS RKNLCEHLQH LKPQWLKAPQ DWSFLSALFF 
121:	CCTVFSTVGY GHMYPVTRLG KFLCMLYALF GIPLMFLVLT DIGDILATIL SRAYSRFQAL 
181:	LCLPHDIFKW RSLPLCRKQP DSKPVEEAIP QIVIDAGVDE LLNPQPSKDP PSPSCNVELF 
241:	ERLVAREKKN KLQPPTRPVE RSNSCPELVL GRLSCSILSN LDEVGQQVER LDIPLPVIAL 
301:	VVFAYISCAA AILPFWETEL GFEDAFYFCF VTLTTIGFGD IVLVHPHFFL FFSIYIIVGM 
361:	EILFIAFKLM QNRLLHTYKT LMLFVCQREV SLPW