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1.A.1.19.2
Sperm-associated cation channel, CatSper2 (6 TMS Ca2+ channel)

Accession Number:Q96P56
Protein Name:Cation channel sperm-associated protein 2
Length:530
Molecular Weight:62041.00
Species: [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell projection1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q96P56
eggNOG: prNOG13458
RefSeq: NP_473361.1    NP_742093.1    NP_742095.1   
Entrez Gene ID: 117155   
Pfam: PF00520   
OMIM: 607249  gene
611102  phenotype
KEGG: hsa:117155   

Gene Ontology

GO:0005929 C:cilium
GO:0020017 C:flagellar membrane
GO:0016021 C:integral to membrane
GO:0005262 F:calcium channel activity
GO:0005515 F:protein binding
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport
GO:0030154 P:cell differentiation
GO:0007275 P:multicellular organismal development
GO:0007283 P:spermatogenesis
GO:0055085 P:transmembrane transport

References (6)

[1] “A voltage-gated ion channel expressed specifically in spermatozoa.”  Quill T.A.et.al.   11675491
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “CATSPER2, a human autosomal nonsyndromic male infertility gene.”  Avidan N.et.al.   12825070
[4] “Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.”  Zhang D.et.al.   16740636
[5] “Sensorineural deafness and male infertility: a contiguous gene deletion syndrome.”  Zhang Y.et.al.   17098888
[6] “Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility.”  Li H.-G.et.al.   17347248

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAYQQEEQM QLPRADAIRS RLIDTFSLIE HLQGLSQAVP RHTIRELLDP SRQKKLVLGD 
61:	QHQLVRFSIK PQRIEQISHA QRLLSRLHVR CSQRPPLSLW AGWVLECPLF KNFIIFLVFL 
121:	NTIILMVEIE LLESTNTKLW PLKLTLEVAA WFILLIFILE ILLKWLSNFS VFWKSAWNVF 
181:	DFVVTMLSLL PEVVVLVGVT GQSVWLQLLR ICRVLRSLKL LAQFRQIQII ILVLVRALKS 
241:	MTFLLMLLLI FFYIFAVTGV YVFSEYTRSP RQDLEYHVFF SDLPNSLVTV FILFTLDHWY 
301:	ALLQDVWKVP EVSRIFSSIY FILWLLLGSI IFRSIIVAMM VTNFQNIRKE LNEEMARREV 
361:	QLKADMFKRQ IIQRRKNMSH EALTSSHSKI EDSSRGASQQ RESLDLSEVS EVESNYGATE 
421:	EDLITSASKT EETLSKKREY QSSSCVSSTS SSYSSSSESR FSESIGRLDW ETLVHENLPG 
481:	LMEMDQDDRV WPRDSLFRYF ELLEKLQYNL EERKKLQEFA VQALMNLEDK