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1.A.1.2.1
Voltage-sensitive K+ channel (PNa+/PK+ ≈ 0.1) Shaker and Shab K+ channels are blocked by quinidine (Gomez-Lagunas, 2010).

Accession Number:P17970
Protein Name:Shab11 aka SHAB aka CG1066
Length:985
Molecular Weight:106359.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: inNOG04617
RefSeq: NP_523894.2    NP_728783.1   
Entrez Gene ID: 38352   
Pfam: PF00520    PF02214   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005251 F:delayed rectifier potassium channel activity
GO:0005515 F:protein binding
GO:0008345 P:larval locomotory behavior
GO:0006813 P:potassium ion transport
GO:0001508 P:regulation of action potential
GO:0008016 P:regulation of heart contraction
GO:0060025 P:regulation of synaptic activity
GO:0055085 P:transmembrane transport

References (6)

[1] “A family of putative potassium channel genes in Drosophila.”  Butler A.et.al.   2493160
[2] “K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.”  Wei A.G.et.al.   2333511
[3] “Shal, Shab, and Shaw: three genes encoding potassium channels in Drosophila.”  Butler A.et.al.   2336395
[4] “Mutational analysis of the Shab-encoded delayed rectifier K(+) channels in Drosophila.”  Hegde P.et.al.   10419540
[5] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[6] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MVGQLQGGQA AGQQQQQQQA TQQQQHSKQQ QQQQQQQQQQ LQLKQHQQQQ QDILYQQHNE 
61:	AIAIARGLQA ATPADIGDNQ PYYDTSGNVD WERAMGAGGA GAYGGIGIGS LPAAGGAAYH 
121:	LGPANPAGLV SRHLDYGDGG HLAGPSAGLP AGAVGSGAGA GAGAGASVTG SGSGAGTGTG 
181:	TGAGSGSGSG AAGKEVRYAP FPVASPTHSI PTTSQQIVGS VGGVGVGGAS SQSISGGVPT 
241:	HSQSNTTGAL QRTHSRSMSS IPPPEPFMIA QSKAVNSRVS INVGGVRHEV LWRTLERLPH 
301:	TRLGRLRECT THEAIVELCD DYSLADNEYF FDRHPKSFSS ILNFYRTGKL HIVDEMCVLA 
361:	FSDDLEYWGV DELYLESCCQ HKYHQRKENV HEEMRKEAES LRQRDEEEFG EGKFSEYQKY 
421:	LWELLEKPNT SFAARVIAVI SILFIVLSTI ALTLNTLPQL QHIDNGTPQD NPQLAMVEAV 
481:	CITWFTLEYI LRFSASPDKW KFFKGGLNII DLLAILPYFV SLFLLETNKN ATDQFQDVRR 
541:	VVQVFRIMRI LRVLKLARHS TGLQSLGFTL RNSYKELGLL MLFLAMGVLI FSSLAYFAEK 
601:	DEKDTKFVSI PEAFWWAGIT MTTVGYGDIC PTTALGKVIG TVCCICGVLV VALPIPIIVN 
661:	NFAEFYKNQM RREKALKRRE ALDRAKREGS IVSFHHINLK DAFAKSMDLI DVIVDTGKQT 
721:	NVVHPKGKRQ STPNIGRQTL DVQSAPGHNL SQTDGNSTEG ESTSGRNPAT TGTGCYKNYD 
781:	HVANLRNSNL HNRRGSSSEQ DAVPPYSFDN PNARQTSMMA MESYRREQQA LLQQQQQQQQ 
841:	QMLQMQQIQQ KAPNGNGGAT GGGVANNLAM VAASSAATAV ATATNASNAS NTAPGSEGAE 
901:	GGGDGDGGGV DDDNLSQAKG LPIQMMITPG EVAELRRQVA LENLQNQRMD NLEQDVPVEF 
961:	ECCFCTTKGL PGCHGECIPL RANSV