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1.A.1.2.17
Potassium voltage-gated channel (KCNH) subfamily G member 3 (Voltage-gated potassium channel subunit Kv10.1) (Voltage-gated potassium channel subunit Kv6.3).  Splice variants have different properties and can activate cyclin-dependent protein kinases (Ramos Gomes et al. 2015). Control of transport (pore) function  by the voltage sensor may involve more than one mechanism (Tomczak et al. 2017).

Accession Number:Q8R523
Protein Name:Potassium voltage-gated channel subfamily G member 3
Length:433
Molecular Weight:49291.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q8R523
eggNOG: COG1226
HEGENOM: HOG000231014
Entrez Gene ID: 171011   
Pfam: PF00520    PF02214   
KEGG: rno:171011   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0008076 C:voltage-gated potassium channel complex
GO:0005249 F:voltage-gated potassium channel activity
GO:0051260 P:protein homooligomerization

References (1)

[1] “Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1.”  Sano Y.et.al.   11852086

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTFGRGGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE 
61:	YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM 
121:	SDTHTFHAAE ELGREQPRPT GPEAAPSRRW LERMRRTFEE PTSSLAAQIL ASVSVVFVIV 
181:	SMVVLCASTL PDWRAAAADN RSLDDRSRYS ASPGREPSGI IEAICIGWFT AECIVRFIVS 
241:	KNKCEFVKRP LNIIDLLAIT PYYISVLMTV FTGENSQLQR AGVTLRVLRM MRIFWVIKLA 
301:	RHFIGLQTLG LTLKRCYREM VMLLVFICVA MAIFSALSQL LEHGLDLETS NKDFASIPAA 
361:	CWWVIISMTT VGYGDMYPIT VPGRILGGVC VVSGIVLLAL PITFIYHSFV QCYHELKFRS 
421:	ARYSRSLSAE FLN