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1.A.1.2.18
Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1)

Accession Number:Q9H3M0
Protein Name:Potassium voltage-gated channel subfamily F member 1
Length:494
Molecular Weight:55584.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9H3M0
eggNOG: COG1226
HEGENOM: HOG000231016
Entrez Gene ID: 3754   
Pfam: PF00520    PF02214   
KEGG: hsa:3754   

Gene Ontology

GO:0005886 C:plasma membrane
GO:0008076 C:voltage-gated potassium channel complex
GO:0005267 F:potassium channel activity
GO:0005249 F:voltage-gated potassium channel activity
GO:0051260 P:protein homooligomerization
GO:0007268 P:synaptic transmission

References (4)

[1] “Isolation, characterization, and mapping of two human potassium channels.”  Su K.et.al.   9434767
[2] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium.”  Godreau D.et.al.   12445884

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDGSGERSLP EPGSQSSAAS DDIEIVVNVG GVRQVLYGDL LSQYPETRLA ELINCLAGGY 
61:	DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM KKGICPICFK NEMDFWKVDL 
121:	KFLDDCCKSH LSEKREELEE IARRVQLILD DLGVDAAEGR WRRCQKCVWK FLEKPESSCP 
181:	ARVVAVLSFL LILVSSVVMC MGTIPELQVL DAEGNRVEHP TLENVETACI GWFTLEYLLR 
241:	LFSSPNKLHF ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI 
301:	FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP ETLFKSIPQS 
361:	FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL PIHPIINNFV RYYNKQRVLE 
421:	TAAKHELELM ELNSSSGGEG KTGGSRSDLD NLPPEPAGKE APSCSSRLKL SHSDTFIPLL 
481:	TEEKHHRTRL QSCK