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1.A.1.2.21
Shal (SHL-1, Kv4) K+ channels of 578 aas and 6 TMSs are the predominant transient outward current in C. elegans muscle. SHL-1 expression occurs in a subset of neurons, body wall muscle and in male-specific diagonal muscles (Fawcett et al. 2006) and control the excitability of neurons and cardiac myocytes by conducting rapidly activating-inactivating currents. Activity is modulated by three K+ channel interacting (KChIP) soluble auxiliary subunits, NCS-4, NCS-5, and NCS-7. All three ceKChIPs alter electrical characteristics of SHL-1 currents by slowing down inactivation kinetics and shifting voltage dependence of activation to more hyperpolarizing potentials. Native SHL-1 current is completely abolished in cultured myocytes of Triple KO worms in which all three KChIP genes are deleted (Chen et al. 2015).

Accession Number:Q95XD1
Protein Name:SHaL family of potassium channels
Length:578
Molecular Weight:66387.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:7
Substrate K+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MASVAAWLPF ARAAAIGWVP ISRQPMPQAP VAIQAKDLAV DHVSDEKLAI NISGRRFETW 
61:	KNTLEKFPET LLGSNEKEFF YDEDTGEYFF DRDPDIFRHI LTFYRTGKLH YPRHECLVAY 
121:	DEELSFFGIM PDLISDCCYE DYKDKKRENQ ERLQEERVEN ADISTLKLSL KEKMWAAFEN 
181:	PHTTSIALVF YYVIGFFIAV SVMCNIVETI PCGYEDNVSV TCGEAYEEQF FVIDTACVII 
241:	FTIEYFLRLI SAPDRIKFMR SIMSVIDVIA IMPYYVSLVL TDNKDVSGLF VTLRVFRVFR 
301:	IFKFSRHSQG LRILGYTLKS CASELGFLVF SLAMAIIIFA TIMYYAEKKV DATRFTSIPS 
361:	AFWYTIVTLT TLGYGDMVPS TIMGKIVGGV CSLSGVLVIA LPVPVIVSNF SRIYHQNQRA 
421:	DKRKAQKKAR LARIRIVKNA SGLALFNKKR AHEARMLAFE QGHLSFDALR DEDIFEIQHH 
481:	HLLQCLEKAT EREFVESEVM FEGGRNTPPP SETASLKGKT KRKRRLCCVS KENEEMEELD 
541:	RETRVTFNQN MDQICELPKP DEMELNHRNN DKICVSQL