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1.A.1.2.6
Voltage-gated K+ channel, Shaker. Shaker and Shab K+ channels are blocked by quinidine (Gomez-Lagunas, 2010). Also regulated by unsaturated fatty acids (Börjesson and Elinder, 2011).  TMSs 3 and 4 comprise the voltage sensor paddle (Xu et al. 2013).  Partially responsible for action potential repolarization during synaptic transmission (Ford and Davis 2014).

Accession Number:P08510
Protein Name:Potassium voltage-gated channel protein Shaker
Length:655
Molecular Weight:74193.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: inNOG06161
RefSeq: NP_001162788.1    NP_523393.3    NP_728120.1    NP_728122.1    NP_728123.1    NP_728124.1    NP_996497.1    NP_996498.1   
Entrez Gene ID: 32780   
Pfam: PF00520    PF02214   
KEGG: dme:Dmel_CG1234   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005515 F:protein binding
GO:0005249 F:voltage-gated potassium channel activity
GO:0048675 P:axon extension
GO:0048150 P:behavioral response to ether
GO:0007619 P:courtship behavior
GO:0009584 P:detection of visible light
GO:0007629 P:flight behavior
GO:0008345 P:larval locomotory behavior
GO:0007611 P:learning or memory
GO:0006813 P:potassium ion transport
GO:0007637 P:proboscis extension reflex
GO:0001508 P:regulation of action potential
GO:0045187 P:regulation of circadian sleep/wake cycle, s...
GO:0060025 P:regulation of synaptic activity
GO:0050909 P:sensory perception of taste
GO:0055085 P:transmembrane transport

References (13)

[1] “Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila.”  Tempel B.L.et.al.   2441471
[2] “Molecular organization of the maternal effect region of the Shaker complex of Drosophila: characterization of an I(A) channel transcript with homology to vertebrate Na(+) channel.”  Baumann A.et.al.   16453805
[3] “Shaker encodes a family of putative potassium channel proteins in the nervous system of Drosophila.”  Pongs O.et.al.   2456921
[4] “Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Drosophila.”  Schwarz T.L.et.al.   2448635
[5] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[6] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[7] “A Drosophila full-length cDNA resource.”  Stapleton M.et.al.   12537569
[8] “Molecular characterization of Shaker, a Drosophila gene that encodes a potassium channel.”  Kamb A.et.al.   2440582
[9] “Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity.”  Kamb A.et.al.   3272175
[10] “Nervous system targets of RNA editing identified by comparative genomics.”  Hoopengardner B.et.al.   12907802
[11] “Reduced sleep in Drosophila Shaker mutants.”  Cirelli C.et.al.   15858564
[12] “Identification of N-glycosylated proteins from the central nervous system of Drosophila melanogaster.”  Koles K.et.al.   17893096
[13] “Three-dimensional structure of the S4-S5 segment of the Shaker potassium channel.”  Ohlenschlaeger O.et.al.   12023222
Structure:
1HO2   1HO7     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAVAGLYGL GEDRQHRKKQ QQQQQHQKEQ LEQKEEQKKI AERKLQLREQ QLQRNSLDGY 
61:	GSLPKLSSQD EEGGAGHGFG GGPQHFEPIP HDHDFCERVV INVSGLRFET QLRTLNQFPD 
121:	TLLGDPARRL RYFDPLRNEY FFDRSRPSFD AILYYYQSGG RLRRPVNVPL DVFSEEIKFY 
181:	ELGDQAINKF REDEGFIKEE ERPLPDNEKQ RKVWLLFEYP ESSQAARVVA IISVFVILLS 
241:	IVIFCLETLP EFKHYKVFNT TTNGTKIEED EVPDITDPFF LIETLCIIWF TFELTVRFLA 
301:	CPNKLNFCRD VMNVIDIIAI IPYFITLATV VAEEEDTLNL PKAPVSPQDK SSNQAMSLAI 
361:	LRVIRLVRVF RIFKLSRHSK GLQILGRTLK ASMRELGLLI FFLFIGVVLF SSAVYFAEAG 
421:	SENSFFKSIP DAFWWAVVTM TTVGYGDMTP VGVWGKIVGS LCAIAGVLTI ALPVPVIVSN 
481:	FNYFYHRETD QEEMQSQNFN HVTSCPYLPG TLGQHMKKSS LSESSSDMMD LDDGVESTPG 
541:	LTETHPGRSA VAPFLGAQQQ QQQPVASSLS MSIDKQLQHP LQQLTQTQLY QQQQQQQQQQ 
601:	QNGFKQQQQQ TQQQLQQQQS HTINASAAAA TSGSGSSGLT MRHNNALAVS IETDV