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1.A.1.2.7
Electrically silent lens epithelium K+ channel (Delayed rectifier K+ channel α-subunit, Kv9.1 (Shepard & Rae, 1999))

Accession Number:Q96KK3
Protein Name:Potassium voltage-gated channel subfamily S member 1 aka KCNS1
Length:526
Molecular Weight:58372.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q96KK3
HEGENOM: HBG445693
RefSeq: NP_002242.2   
Entrez Gene ID: 3787   
Pfam: PF00520    PF02214   
OMIM: 602905  gene
KEGG: hsa:3787   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005251 F:delayed rectifier potassium channel activity
GO:0015459 F:potassium channel regulator activity
GO:0005515 F:protein binding
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “Electrically silent potassium channel subunits from human lens epithelium.”  Shepard A.R.et.al.   10484328
[2] “The DNA sequence and comparative analysis of human chromosome 20.”  Deloukas P.et.al.   11780052
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLMLLVRGTH YENLRSKVVL PTPLGGRSTE TFVSEFPGPD TGIRWRRSDE ALRVNVGGVR 
61:	RQLSARALAR FPGTRLGRLQ AAASEEQARR LCDDYDEAAR EFYFDRHPGF FLSLLHFYRT 
121:	GHLHVLDELC VFAFGQEADY WGLGENALAA CCRARYLERR LTQPHAWDED SDTPSSVDPC 
181:	PDEISDVQRE LARYGAARCG RLRRRLWLTM ENPGYSLPSK LFSCVSISVV LASIAAMCIH 
241:	SLPEYQAREA AAAVAAVAAG RSPEGVRDDP VLRRLEYFCI AWFSFEVSSR LLLAPSTRNF 
301:	FCHPLNLIDI VSVLPFYLTL LAGVALGDQG GKEFGHLGKV VQVFRLMRIF RVLKLARHST 
361:	GLRSLGATLK HSYREVGILL LYLAVGVSVF SGVAYTAEKE EDVGFNTIPA CWWWGTVSMT 
421:	TVGYGDVVPV TVAGKLAASG CILGGILVVA LPITIIFNKF SHFYRRQKAL EAAVRNSNHQ 
481:	EFEDLLSSID GVSEASLETS RETSQEGQSA DLESQAPSEP PHPQMY