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1.A.1.20.2
Erg2 (Kv11.2) K+ channel with slowly activating delayed rectifier (expressed only in the nervous system) (Shi et al., 1997)

Accession Number:O54853
Protein Name:Potassium voltage-gated channel subfamily H member 6 aka Kcnh6 aka Erg2
Length:950
Molecular Weight:105706.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O54853
eggNOG: maNOG17870
RefSeq: NP_446389.1   
Entrez Gene ID: 116745   
Pfam: PF00027    PF00520    PF00989   
KEGG: rno:116745   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport
GO:0051291 P:protein heterooligomerization
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0007165 P:signal transduction
GO:0055085 P:transmembrane transport

References (4)

[1] “Identification of two nervous system-specific members of the erg potassium channel gene family.”  Shi W.et.al.   9390998
[2] “Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.”  Wulfsen I.et.al.   10718922
[3] “Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.”  Wimmers S.et.al.   11212207
[4] “Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.”  Saganich M.J.et.al.   11425889

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE LFGYSRVEVM 
61:	QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR KDASSFRCLV DVVPVKNEDG 
121:	AVIMFILNFE DLAQLLAKSS SRSLTQRLLS HSFLGSEGSH SRPSGQGPGP GRGKYRTVSQ 
181:	IPQFTLNFVE FNLEKHRSGS TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ 
241:	APRIHRGTIL HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESQR GTCGYTCSPL 
301:	TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM VAAIPFDLLI 
361:	FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY 
421:	AIGNVERPYL EPKIGWLDSL GAQLGKQYNG SDPASGPSVQ DKYVTALYFT FSSLTSVGFG 
481:	NVSPNTNSEK VFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ 
541:	IPNPLRQRLE EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK 
601:	GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI LGKNDIFGEP 
661:	ASLHARPGKS SADVRALTYC DLHKIHRADL LEVLDMYPAF ADTFWNKLEV TFNLRDADGG 
721:	LQSTPRQAPG HQDPQGFFLN DSQSGAAPSL SISDTSALWP ELLQQMPPSP PNPRQDLDCW 
781:	HRELGFKLEQ LQAQMNRLES RVSSDLSRIL QLLQHPQGRP SYILGASASS DLASFPETSV 
841:	TRSSESTLLV GHVPSAQTLS YGDLDDHIQT PRNFSPRTPH VAMAMDKTLV PSSEQEQPGG 
901:	LLSPLASPLR PLEVPGLGGS RFPSLPEHLS SVPKQLEFQR HGSDPGFTRS