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1.A.1.5.14
Probable cyclic nucleotide-gated ion channel 6 (AtCNGC6) (Cyclic nucleotide- and calmodulin-regulated ion channel 6)

Accession Number:O82226
Protein Name:Probable cyclic nucleotide-gated ion channel 6
Length:747
Molecular Weight:85441.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

Genevestigator: O82226
eggNOG: NOG291133
HEGENOM: HOG000238338
Entrez Gene ID: 816931   
Pfam: PF00027    PF00520   
KEGG: ath:AT2G23980   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0030552 F:cAMP binding
GO:0030553 F:cGMP binding
GO:0005249 F:voltage-gated potassium channel activity
GO:0046686 P:response to cadmium ion

References (3)

[1] “Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.”  Koehler C.et.al.   10341447
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
Structure:
1WGP     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG PKRFAQGSKA 
61:	SSGSFKKGFR KGSEGLWSIG RSIGLGVSRA VFPEDLEVSE KKIFDPQDKF LLLCNKLFVA 
121:	SCILAVSVDP LFLYLPFIND KAKCVGIDRK LAIIVTTIRT VIDSFYLFHM ALRFRTAYVA 
181:	PSSRVFGRGE LVIDPAQIAK RYLQQYFIID LLSVLPVPQI IVWRFLYTSR GANVLATKQA 
241:	LRYIVLVQYI PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH IVGALWYLLA 
301:	LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV NVPEDEEPPF 
361:	DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG LETSTYPGEV IFSITLAIAG 
421:	LLLFALLIGN MQTYLQSLTI RLEEMRVKRR DSEQWMHHRM LPPELRERVR RYDQYKWLET 
481:	RGVDEENLVQ NLPKDLRRDI KRHLCLALVR RVPLFENMDE RLLDAICERL KPCLFTEKSY 
541:	LVREGDPVNE MLFIIRGRLE SVTTDGGRSG FYNRSLLKEG DFCGDELLTW ALDPKSGSNL 
601:	PSSTRTVKAL TEVEAFALIA DELKFVASQF RRLHSRQVQH TFRFYSQQWR TWAACFMQAA 
661:	WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF LASKFAANAL RSVHKNRTAK 
721:	STLLLSSTKE LVKFQKPPEP DFSAEDH