Putative cyclic AMP receptor protein (Crp), annotated in GenBank as a Crp homologue with a CAP_ED domain N-terminal and a helix-turn-hexix (HTH) domain C-terminal. This protein has two poorly hydrophobic peaks at ~ residue # 85 and 165, with a potential "P-loop" between these two peaks. All of the cyclic nucleotide regulated channels in subfamily 2.A.1.5 have the two TMSs separated by about 80 residues with the P-loop inbetween. Maybe the cAMP binding domains in the transcription factors and the channel proteins are derived from a common origin, and are therefore homologous.
|Protein Name:||Putative transcriptional regulator, Crp/Fnr family|
|Species:||Bifidobacterium longum subsp. longum (strain JDM301)  |
1: MSLETPNAFA DEENILLHTA LFKQVSPAEA EELLPHLKRA TFDKGDYIFS EGDTDQRMYL
61: LEQGRVKLIR TSSDDRVQLL SIHAPGEVLG EIPVFDPHGG PRTASAVSMS HGTRVVWLEH
121: DALFAWLDEH PRVAIDMLQV MANRQRGNNE RISDLVFMDV PARLAKTLLN LGSRFGEPVE
181: QGLKVPHDLT QEELAQLVGS SRETVNKALM DFSNRGWIAR DGRSIIIFQP GMLIRRSRR