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1.A.1.8.1
TWIK-1 inward rectifier K+ channel (Enyedi and Czirják, 2010).  Lipid tails from both the upper and lower leaflets can partially penetrate into the pore (Aryal et al. 2015). The lipid tails do not sterically occlude the pore, but there is an inverse correlation between the presence of water within the hydrophobic barrier and the number of lipids tails within the lining of the pore (Aryal et al. 2015).

Accession Number:O08581
Protein Name:TWIK-1 aka KCNK1
Length:336
Molecular Weight:38275.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O08581
eggNOG: roNOG07191
HEGENOM: HBG446730
RefSeq: NP_032456.2   
Entrez Gene ID: 16525   
Pfam: PF07885   
KEGG: mmu:16525   

Gene Ontology

GO:0005768 C:endosome
GO:0016021 C:integral to membrane
GO:0005267 F:potassium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0006813 P:potassium ion transport

References (3)

[1] “The structure, function and distribution of the mouse TWIK-1 K+ channel.”  Lesage F.et.al.   9013852
[2] “Structure, chromosome localization, and tissue distribution of the mouse twik K+ channel gene.”  Arrighi I.et.al.   9559671
[3] “Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.”  Munton R.P.et.al.   17114649
Structure:
3ukm     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSEELPYED LLRQELRKLK 
61:	RRFLEEHECL SEPQLEQFLG RVLEASNYGV SVLSNASGNW NWDFTSALFF ASTVLSTTGY 
121:	GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT ALVQRVTVHV TRRPVLYFHI RWGFSKQVVA 
181:	IVHAVLLGFV TVSCFFFIPA AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK 
241:	FRELYKIGIT CYLLLGLITM LVVLETFCEL HELKKFRKMF YVKKDKDEDL VHIMEHDQLS 
301:	FSSVTEQVAG LKEEQKQSEP FVASQSPPYE DGSADH