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1.A.1.9.1
TREK-1 K+ channel subunit (Regulated by group 1 metabotropic glutamate receptors and by diacylglycerols and phosphatidic acids) (Chemin et al., 2003). TREK-1, TREK-2 and TRAAK are all regulated by lysophosphatidic acid, converting these mechano-gated, pH voltage-sensitive channels into leak conductances (Chemin et al., 2005). The mammalian K2P2.1 potassium channel (TREK-1, KCNK2) is highly expressed in excitable tissues, where it plays a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain perception and depression (Cohen et at., 2008). Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium (Thomas et al. 2008). The crystal structure of the human 2-pore domain K+ channel, K2P1 has been solved (Miller and Long, 2012). Multiple modalities converge on a common gate to control K2P channel function (Bagriantsev et al., 2011).  TREK-1 mediates fast and slow glutamate release in astrocytes upon GPCR activation (Woo et al. 2012). It is a mechanosensitive K+ channel, present in rat bladder myocytes, which is activated by swelling and arachidonic acid (Fukasaku et al. 2016). The M2-hinges of TREK-1 and TREK-2 channels control their macroscopic current, subcellular localization and gating (Zhuo et al. 2017).

Accession Number:P97438
Protein Name:TREK-1 aka KCNK2
Length:411
Molecular Weight:45298.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: P97438
eggNOG: roNOG04864
HEGENOM: HBG717586
RefSeq: NP_034737.2   
Entrez Gene ID: 16526   
Pfam: PF07885   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005249 F:voltage-gated potassium channel activity
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0006813 P:potassium ion transport
GO:0030322 P:stabilization of membrane potential

References (2)

[1] “Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.”  Fink M.et.al.   9003761
[2] “Inhalational anesthetics activate two-pore-domain background K+ channels.”  Patel A.J.et.al.   10321245
Structure:
4twk     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAPDLLDPK SAAQNSKPRL SFSSKPTVLA SRVESDSAIN VMKWKTVSTI FLVVVLYLII 
61:	GAAVFKALEQ PQEISQRTTI VIQKQTFIAQ HACVNSTELD ELIQQIVAAI NAGIIPLGNS 
121:	SNQVSHWDLG SSFFFAGTVI TTIGFGNISP RTEGGKIFCI IYALLGIPLF GFLLAGVGDQ 
181:	LGTIFGKGIA KVEDTFIKWN VSQTKIRIIS TIIFILFGCV LFVALPAVIF KHIEGWSALD 
241:	AIYFVVITLT TIGFGDYVAG GSDIEYLDFY KPVVWFWILV GLAYFAAVLS MIGDWLRVIS 
301:	KKTKEEVGEF RAHAAEWTAN VTAEFKETRR RLSVEIYDKF QRATSVKRKL SAELAGNHNQ 
361:	ELTPCRRTLS VNHLTSEREV LPPLLKAESI YLNGLTPHCA GEDIAVIENM K