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1.A.1.9.9
TWiK family of potassium channels protein 12

Accession Number:Q19907
Protein Name:TWiK family of potassium channels protein 12
Length:713
Molecular Weight:82068.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: NOG285024
HEGENOM: HOG000018845
Entrez Gene ID: 192074   
Pfam: PF07885   
KEGG: cel:F29F11.4   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005267 F:potassium channel activity

References (2)

[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[2] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTLFKKIQWF CNLIRLRSYY KFLLLIAYTA FGAWLFRTYE LQADIKRRSV FGNTTNLVRR 
61:	QLAERWIEMH KDAVLRNDSA LRFRRAAEAV EWLLDELNLS DHIRDLSEET PWTWTGAMFY 
121:	AGQLYTTIGY GYPTTKTDEG RICTIFYALF GIPCFLMYLK IENAIEWKKD KQLGKRALKM 
181:	HGLINDSFQS IGKTLSKKMK KYYKKLRRSR VGRILLPTRV TAMKDGFEDP EAAEERKKKP 
241:	FPIPIAIIML IIWICFSASM FCIWEDTWVF SSAVYFFIVS ISTVGLGDML FRTPDMMVFN 
301:	FLLILVGLAL LSMCFELITD RVAKWKQKRF DEHIKKVQKM AFQVFEKDPF IEEAPPLGIR 
361:	MAPNLMQIAA THVSEEKRGF FAEFKDWFAG KVTDNVIQSK LEDSDDESDS EEALEEFDSP 
421:	QIATVTANDL IVCSNGAATR RVSKQSYALS DISNLSNSKI LPGNNYGQLL DRIKAMEKFK 
481:	PKKNDLDSRM FAKFLENKKL AKILEQTELR ELATVSCQTD LSGLVVQRRN PKGRHARIGS 
541:	CSSQSTMSTL LPNKMHAPDE DSVMSFTFGD LKFDYKTEPF IDEYYIRESN HSIFDFDEDE 
601:	TVRIPQKMLI SRPGMPPPPP SRPLNLASPL RTLLEKEQKY DEDPEIQLTP RRLNSLSDIQ 
661:	ARKVKLGVDE NLQHARLVCG LLPQDFDSPS TSTSTSMIDS GYELSKRDAS TMA