TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.10.1.25
NMDA receptor subtype 1, NMDAR1, of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission and is involved in cell surface targeting of NMDA receptors. It plays a role in associative learning and in long-term memory consolidation (Xia et al. 2005). F654A and K558Q mutations affect ethanol-induced behaviors in Drosophila.(Troutwine et al. 2019).
 

Accession Number:Q24418
Protein Name:Glutamate [NMDA] receptor subunit 1
Length:997
Molecular Weight:112288.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MAMAEFVFCR PLFGLAIVLL VAPIDAAQRH TASDNPSTYN IGGVLSNSDS EEHFSTTIKH 
61:	LNFDQQYVPR KVTYYDKTIR MDKNPIKTVF NVCDKLIENR VYAVVVSHEQ TSGDLSPAAV 
121:	SYTSGFYSIP VIGISSRDAA FSDKNIHVSF LRTVPPYYHQ ADVWLEMLSH FAYTKVIIIH 
181:	SSDTDGRAIL GRFQTTSQTY YDDVDVRATV ELIVEFEPKL ESFTEHLIDM KTAQSRVYLM 
241:	YASTEDAQVI FRDAGEYNMT GEGHVWIVTE QALFSNNTPD GVLGLQLEHA HSDKGHIRDS 
301:	VYVLASAIKE MISNETIAEA PKDCGDSAVN WESGKRLFQY LKSRNITGET GQVAFDDNGD 
361:	RIYAGYDVIN IREQQKKHVV GKFSYDSMRA KMRMRINDSE IIWPGKQRRK PEGIMIPTHL 
421:	RLLTIEEKPF VYVRRMGDDE FRCEPDERPC PLFNNSDATA NEFCCRGYCI DLLIELSKRI 
481:	NFTYDLALSP DGQFGHYILR NNTGAMTLRK EWTGLIGELV NERADMIVAP LTINPERAEY 
541:	IEFSKPFKYQ GITILEKKPS RSSTLVSFLQ PFSNTLWILV MVSVHVVALV LYLLDRFSPF 
601:	GRFKLSHSDS NEEKALNLSS AVWFAWGVLL NSGIGEGTPR SFSARVLGMV WAGFAMIIVA 
661:	SYTANLAAFL VLERPKTKLS GINDARLRNT MENLTCATVK GSSVDMYFRR QVELSNMYRT 
721:	MEANNYATAE QAIQDVKKGK LMAFIWDSSR LEYEASKDCE LVTAGELFGR SGYGIGLQKG 
781:	SPWTDAVTLA ILEFHESGFM EKLDKQWIFH GHVQQNCELF EKTPNTLGLK NMAGVFILVG 
841:	VGIAGGVGLI IIEVIYKKHQ VKKQKRLDIA RHAADKWRGT IEKRKTIRAS LAMQRQYNVG 
901:	LNSTHAPGTI SLAVDKRRYP RLGQRLGPER AWPGDAADVL RIRRPYELGN PGQSPKVMAA 
961:	NQPGMPMPML GKTRPQQSVL PPRYSPGYTS DVSHLVV