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1.A.10.1.26
Ionotropic receptor 21a, Ir21a, of 842 aas and 5 TMSs.  Ir21a is a cooling receptor that drives heat seaking in insects to their warm blooded hosts (Greppi et al. 2020).  Although Ir21a mediates heat avoidance in Drosophila, it drives heat seeking and heat-stimulated blood feeding in Anopheles. At a cellular level, Ir21a is essential for the detection of cooling, suggesting that during evolution, mosquito heat seeking relied on cooling-mediated repulsion. Thus, the evolution of blood feeding in Anopheles involves repurposing an ancestral thermoreceptor from non-blood-feeding Diptera (Greppi et al. 2020).

Accession Number:Q9VPI2
Protein Name:Ionotropic receptor 21a
Length:842
Molecular Weight:95565.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MSYYWVALVL FTAQAFSIEG DRSASYQEKC ISRRLINHYQ LNKEIFGVGM CDGNNENEFR 
61:	QKRRIVPTFQ GNPRPRGELL ASKFHVNSYN FEQTNSLVGL VNKIAQEYLN KCPPVIYYDS 
121:	FVEKSDGLIL ENLFKTIPIT FYHGEINADY EAKNKRFTSH IDCNCKSYIL FLSDPLMTRK 
181:	ILGPQTESRV VLVSRSTQWR LRDFLSSELS SNIVNLLVIG ESLMADPMRE RPYVLYTHKL 
241:	YADGLGSNTP VVLTSWIKGA LSRPHINLFP SKFQFGFAGH RFQISAANQP PFIFRIRTLD 
301:	SSGMGQLRWD GVEFRLLTMI SKRLNFSIDI TETPTRSNTR GVVDTIQEQI IERTVDIGMS 
361:	GIYITQERLM DSAMSVGHSP DCAAFITLAS KALPKYRAIM GPFQWPVWVA LICVYLGGIF 
421:	PIVFTDRLTL SHLMGNWGEV ENMFWYVFGM FTNAFSFTGK YSWSNTRKNS TRLLIGAYWL 
481:	FTIIITSCYT GSIIAFVTLP AFPDTVDSVL DLLGLFFRVG TLNNGGWETW FQNSTHIPTS 
541:	RLYKKMEFVG SVDEGIGNVT QSFFWNYAFL GSKAQLEYLV QSNFSDENIS RRSALHLSEE 
601:	CFALFQIGFL FPRESVYKIK IDSMILLAQQ SGLIAKINNE VSWVMQRSSS GRLLQASSSN 
661:	SLREIIQEER QLTTADTEGM FLLMALGYFL GATALVSEIV GGITNKCRQI IKRSRKSAAS 
721:	SWSSASSGSM LRTNAEQLSH DKRKANRREA AEVAQKMSFG MRELNLTRAT LREIYGSYGA 
781:	PETDHGQLDI VHTEFPNSSA KLNNIEDEES REALESLQRL DEFMDQMDND GNPSSHTFRI 
841:	DN