TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
*1.A.13.1.1









Voltage-gated bovine epithelial Cl- channel protein (Ca2+-activated), bEClC. In rats, two possible paralogues (rbCLCA1 and A2) are expressed in the CNS and peripheral organs (Yoon et al., 2006). CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015).

Eukaryota
Metazoa
EClC of Bos taurus (NP_001070824)
*1.A.13.1.2









Ca2+-activated Cl- channel-2, CaCC-2
Eukaryota
Metazoa
CaCC-2 of Homo sapiens
*1.A.13.1.3









The Ca-activated chloride channel-6 (Lee et al., 2011).

Eukaryota
Metazoa
Ca-CLC-6 of Xenopus laevis (F7IYU6)
*1.A.13.1.4









Calcium-activated chloride channel regulator family member 3 (Calcium-activated chloride channel family member 3) (hCLCA3)
Eukaryota
Metazoa
CLCA3P of Homo sapiens
*1.A.13.1.5









Putative lipoprotein of 1054 aas and 1-3 TMSs.

Bacteria
Spirochaetes
Putative lipoprotein of Leptospira biflexa
*1.A.13.1.6









Ca+2-activated Cl- channel, CLCA1 or CACC1 or 914 aas.  CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015Sala-Rabanal et al. 2015).

Eukaryota
Metazoa
CLCA1 of Homo sapiens
*1.A.13.1.7









xCLCA3; xCLCA2 of 942 aas and 7 TMSs.  xCLCA3 contains a predicted signal sequence, multiple sites of N-linked glycosylation, N-myristoylation, PKA, PKC, and casein kinase II phosphorylation sites, five putative hydrophobic segments, and the HExxH metalloprotease motif. Additionally, the transmembrane prediction server yielded a preserved N-terminal CLCA domain and a von Willebrand factor type A domain with one transmembrane domain in the C-terminal region (Lee and Jeong 2016). xCLCA3 is expressed in a number of tissues, with strong expression in the brain, colon, small intestine, lung, kidney, and spleen, and poor expression in the heart and liver. xCLCA3 may be a candidate CLCA family member as well as a metalloprotease, rather than just an ion channel accessory protein.

Eukaryota
Metazoa
xCLCA3 of Xenopus laevis (African clawed frog)
*1.A.13.2.1









Hypothetical protein, HP

Eukaryota
Viridiplantae
HP of Oryza sativa (B8AFH9)
*1.A.13.2.2









Sll0103

Bacteria
Cyanobacteria
Sll0103 of Synechocystis (Q55874)
*1.A.13.2.3









The YfbK/CaClC homologue of 575aas and 0 TMSs.  YfbK has amyloidogenic regions due to asparagine- and glutamine-rich regions which is a common feature of many known amyloid proteins. This correlates with detergent-induced denaturation resistance (Antonets et al. 2016).

Bacteria
Proteobacteria
YfbK of E. coli (P76481)
*1.A.13.3.1









Von Willebrand factor type A protein, vWFA. (905 aas; 2 N-terminal and 1 C-terminal TMSs)

Bacteria
Chloroflexi
vWFA of Chloroflexus aurantiacus (A9WIT9)
*1.A.13.4.1









Bacterial homologue, BatB, of mammalian Ca-CLC channels (N- and C-terminal TMSs)

Bacteria
Proteobacteria
BatB of Myxococcus fulvus (F8CM01)
*1.A.13.5.1









Uncharacterized protein of 252 aas and 2-3 TMSs

Bacteria
Proteobacteria
UP of E. coli