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1.A.14.1.1
The Bax Inhibitor-1, BI-1 of 311 aas and 6 TMSs is also called the testis-enhanced gene transcript (TEGT) protein or the transmembrane BAX inhibitor motif-containing protein 6 (TMBIM6).  It forms an ER, pH-sensitive, cation-selective, Ca2+-permeable leak channel (Bultynck et al., 2011; Chang et al. 2014).  Residues that contribute to the ion-conducting pore and affect apoptosis, cell adhesion and migration independently have been identified (Carrara et al. 2015). The TMBIM6 calcium leak channel activity negatively regulates autophagy and autophagosome formation, influencing cardovascular traits (Swain et al. 2020). It enhances autophagy through regulation of lysosomal calcium (Kim et al. 2020). A TMBIM6 deficiency enhances susceptibility to ER stress due to inhibition of the ER stress sensor IRE1alpha. Its overexpression improves glucose metabolism, and knockout mice develop obesity (Philippaert et al. 2020). TMBIM6 knockout mice feature high glucose-stimulated insulin secretion in vivo. This coincides with profound changes in glucose-mediated Ca2+ regulation in isolated pancreatic beta cells and increases levels of IRE1alpha levels. TMBIM6-mediated metabolic alterations are mainly caused by its role as a Ca2+ release channel in the ER. Thus, TMBIM6(-/-) leads to obesity and hepatic steatosis by blocking Ca2+ transport (Philippaert et al. 2020).

Accession Number:P55061
Protein Name:BI1 aka TEGT
Length:237
Molecular Weight:26538.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: P55061 P55061 P55061
eggNOG: prNOG16733 prNOG16733 prNOG16733
HEGENOM: HBG627476 HBG627476 HBG627476
RefSeq: NP_001092046.1    NP_003208.2   
Entrez Gene ID: 7009   
Pfam: PF01027   
OMIM: 600748  gene
KEGG: hsa:7009    hsa:7009    hsa:7009   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0005626 C:insoluble fraction
GO:0005887 C:integral to plasma membrane
GO:0005634 C:nucleus
GO:0006915 P:apoptosis
GO:0043066 P:negative regulation of apoptosis
GO:0006915 P:apoptotic process
GO:0043066 P:negative regulation of apoptotic process

References (15)

[1] “Identification of a novel conserved human gene, TEGT.”  Walter L.et.al.   8530040
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.”  Xu Q.et.al.   9660918
[5] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.”  Meierhofer D.et.al.   18781797
[6] “Identification of a novel conserved human gene, TEGT.”  Walter L.et.al.   8530040
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.”  Xu Q.et.al.   9660918
[10] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.”  Meierhofer D.et.al.   18781797
[11] “Identification of a novel conserved human gene, TEGT.”  Walter L.et.al.   8530040
[12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[13] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[14] “Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.”  Xu Q.et.al.   9660918
[15] “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.”  Meierhofer D.et.al.   18781797

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FASTA formatted sequence
1:	MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS 
61:	ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG 
121:	TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV 
181:	MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK