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1.A.14.3.12
Viroporin, pUS21, of 243 aas and 8 TMSs.  It modulates calcium ion homeostasis and protects cells against apoptosis (Luganini et al. 2018).  pUS21 of HCMV constitutes a TMBIM-derived viroporin that may contribute to HCMV's overall strategy to counteract apoptosis of infected cells.

Accession Number:F5HHT6
Protein Name:Membrane protein US21
Length:243
Molecular Weight:26927.00
Species:Human cytomegalovirus (strain Merlin) (HHV-5) [295027]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Host membrane1 / Multi-pass membrane protein2
Substrate

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FASTA formatted sequence
1:	MSLRGQVQIA RSVFLLRIYI LIWVQCLILM SVCAFCWLVL PHRLEQLFSS VRLTLSCLMI 
61:	SIVCLGLLRW AEPNFPKNVW ILLTYTLLTS VAVTASGFHF SHRSVIYAMV ATVTLFCFLT 
121:	LATYLFARDV ELQRSLLTGA STLILLLFAV FSLFPEAVSE ILVMIAGLAV IVTSVVCDTQ 
181:	DILHDIEYES YIPGALCLYM DLMYLFVSVL YFMPSEPGSA HTAQTTVAAT VAATAAASPQ 
241:	FVS